Quantum Dots for Quantitative Multiplex strips test for Folate and Surrogate Metabolites.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$150,000.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
200-2012-M-52244
Award Id:
n/a
Agency Tracking Number:
HHS2002012M52244
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Ocean Nano Tech LLC (Currently OCEAN NANOTECH, LLC)
Springdale, AR, 72764-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
155516987
Principal Investigator:
Zoraida Aguilar
zaguilar@oceannanotech.com
Business Contact:
Zoraida Aguilar
zaguilar@oceannanotech.com
Research Institution:
n/a
Abstract
Our goal is to develop easy1to use, inexpensive, and sensitive quantum dots(QDs) or quantum dots nano beads (QDnBs or QDBs) based rapid diagnostic strip test for folate and surrogate metabolites (homocysteine and methylmalonate) in a multiplex assay using quantum dots/quantum dots nano beads based lateral flow strip tests as Ri;Jpid Diagnostic Tests (RDTs) in plasma and/or RBCs called Folate-QDT. This will detect as low as 0.1 ng/mL folate in serum or red blood cells (RBCs) in a <20 min assay. It also detects homocysteine, He, (> 12 uinol/L), and methylmalonate, Mm (>450 nmol/L66) as confirmatory tests to folate deficiency which provides a:measure of vitamin 812 deficiency through the detection of methylmalonate. This is aimed at preventing neural tube defects (NTD) that are serious birth defects of the brain and spine that can be prevel\led if a woman consumes folic acid before and during early pregnancy. Pregnant women need extra folic acid to make more red blood cells and maintain normal growth of their baby. Women who do not get enough folic acid before and during pregnancy are more likely to have a child born with other birth defects such as a cleft lip or cleft palate.

* information listed above is at the time of submission.

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