Point-of-care immunoassay for diagnosis of cryptococcosis in HIV/AIDS from whole blood

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 200-2012M53295
Agency Tracking Number: HHS2002012M53295
Amount: $149,891.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
Immuno-Mycologics INC
Norman, OK, 73071-
Duns: 099550915
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Sean Bauman
 sean-bauman@immy.com
Business Contact
 Sean Bauman
Email: sean-bauman@immy.com
Research Institution
N/A
Abstract
Cryptococcal meningitis (CM) kills more than 600,000 HIV-infected individuals globally per year, with the highest yearly incidence occurring in sub-Saharan Africa. There is a critical need for a simple diagnostic tool for cryptococcosis that can be used in resource-limited countries. An innovative cryptococcal antigen lateral flow assay (CrAg LFA) has been developed in order to address this need. The CrAg LFA has been shown to be effective for use with serum, plasma, cerebral spinal fluid, and urine specimens, but has not been optimized or evaluated for use with whole blood specimens, which is the ideal specimen type for resource limited countries with minimal laboratory infrastructure. The specific aims and anticipated results are the optimization of the CrAg LFA and the determination of the range of detection of CrAg in whole blood specimens. The success of this proposed study would have a profound public health impact, leading to earlier diagnosis of cryptococcosis and a reduction of CM-associated deaths.

* information listed above is at the time of submission.

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