Point-of-care immunoassay for diagnosis of cryptococcosis in HIV/AIDS from whole blood

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$149,891.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
200-2012M53295
Award Id:
n/a
Agency Tracking Number:
HHS2002012M53295
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Norman, OK, 73071-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
099550915
Principal Investigator:
Sean Bauman
sean-bauman@immy.com
Business Contact:
Sean Bauman
sean-bauman@immy.com
Research Institute:
n/a
Abstract
Cryptococcal meningitis (CM) kills more than 600,000 HIV-infected individuals globally per year, with the highest yearly incidence occurring in sub-Saharan Africa. There is a critical need for a simple diagnostic tool for cryptococcosis that can be used in resource-limited countries. An innovative cryptococcal antigen lateral flow assay (CrAg LFA) has been developed in order to address this need. The CrAg LFA has been shown to be effective for use with serum, plasma, cerebral spinal fluid, and urine specimens, but has not been optimized or evaluated for use with whole blood specimens, which is the ideal specimen type for resource limited countries with minimal laboratory infrastructure. The specific aims and anticipated results are the optimization of the CrAg LFA and the determination of the range of detection of CrAg in whole blood specimens. The success of this proposed study would have a profound public health impact, leading to earlier diagnosis of cryptococcosis and a reduction of CM-associated deaths.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government