Pincer Assays for Detecting Early Hepatitis C

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 200-2012-52857
Agency Tracking Number: HHS200201252857
Amount: $737,952.00
Phase: Phase II
Program: SBIR
Awards Year: 2012
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
St. Louis, MO, 63110-
DUNS: 100512883
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Ling Tian
Business Contact
 Ling Tian
Research Institution
Early diagnosis of the hepatitis C virus (HCV) infection is crucial for treatment and prevention. PCR screening and ELISA-based assay are currently used to detect viral RNA and HCV antibodies in patient blood samples. There are, however, no commercially available serological assays which can discriminate between acute and chronic HCV infection. In the phase I project, the company developed magnetic bead-based PINCER assay as well as homogeneous PINCER assays for quick detection of anti-HCV IgG and IgM. To continue this project, it is proposed to 1. Validate the magnetic beads-based PINCER assay with patient samples, 2. Develop homogeneous PINCER assays using a complete panel of HCV antigens and validate the assays with clinical samples and 3. Develop and validate PINCER assays for HCV core antigen. It is expected that after successfully implementing the phase II project, the company will provide a unique set of simple, robust and cost-effective screening tools for detection of anti-HCV antibody and antigens for diagnosis of acute and chronic HCV infection

* Information listed above is at the time of submission. *

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