Pincer Assays for Detecting Early Hepatitis C

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$737,952.00
Award Year:
2012
Program:
SBIR
Phase:
Phase II
Contract:
200-2012-52857
Agency Tracking Number:
HHS200201252857
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Mediomics, LLC
St. Louis, MO, 63110-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
100512883
Principal Investigator:
Ling Tian
TianL@Mediomics.com
Business Contact:
Ling Tian
TianL@Mediomics.com
Research Institution:
n/a
Abstract
Early diagnosis of the hepatitis C virus (HCV) infection is crucial for treatment and prevention. PCR screening and ELISA-based assay are currently used to detect viral RNA and HCV antibodies in patient blood samples. There are, however, no commercially available serological assays which can discriminate between acute and chronic HCV infection. In the phase I project, the company developed magnetic bead-based PINCER assay as well as homogeneous PINCER assays for quick detection of anti-HCV IgG and IgM. To continue this project, it is proposed to 1. Validate the magnetic beads-based PINCER assay with patient samples, 2. Develop homogeneous PINCER assays using a complete panel of HCV antigens and validate the assays with clinical samples and 3. Develop and validate PINCER assays for HCV core antigen. It is expected that after successfully implementing the phase II project, the company will provide a unique set of simple, robust and cost-effective screening tools for detection of anti-HCV antibody and antigens for diagnosis of acute and chronic HCV infection

* information listed above is at the time of submission.

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