A Miniature Autoinjector for Multicomponent Drugs and Vaccines

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911QY-13-P-0167
Agency Tracking Number: C131-106-0047
Amount: $99,962.00
Phase: Phase I
Program: SBIR
Awards Year: 2013
Solicitation Year: 2013
Solicitation Topic Code: CBD13-106
Solicitation Number: 2013.1
Small Business Information
Creare Inc.
P.O. Box 71, Hanover, NH, -
DUNS: 072021041
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Michael Jaeger
 Principal Investigator
 (603) 643-3800
Business Contact
 Robert Kline-Schoder
Title: President
Phone: (603) 643-3800
Email: contractsmgr@creare.com
Research Institution
Chemical, biological, or toxin attacks in military and civilian settings are a serious and growing concern. Standard first aid for exposure to many chemical warfare agents and toxins includes the immediate administration of relevant antidotes using an autoinjector. When an attack occurs, prefilled autoinjectors must be immediately available and thus highly portable, and they must be suitable for use by nonmedical personnel. Similarly, rapid distribution and administration of targeted vaccines is critical during a biological outbreak. Storage of drug formulations as separate components within the injector (e.g., a dry medication and a diluent) can significantly extend the shelf life of many medications. Creare proposes to develop a novel miniaturized autoinjector that automatically mixes two or more pre-filled components immediately prior to injection. The drug storage and reconstitution method is based on Creare"s recently patented technology for disposable, pre-filled drug cartridges and is applicable to single-component, dry/wet, liquid/liquid, and multicomponent combinations. In Phase I, we will develop preliminary autoinjector designs and perform laboratory tests of key actuator functions to illustrate the device form and feasibility. In the Option phase, we will develop detailed designs of the actuator mechanisms, and in Phase II we will design, produce, and test prototype autoinjector devices.

* information listed above is at the time of submission.

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