Rapid biodosimetry for accurate assessment of individual radiation exposure levels

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911QY-13-P-0172
Agency Tracking Number: C131-108-0041
Amount: $99,995.00
Phase: Phase I
Program: SBIR
Awards Year: 2013
Solicitation Year: 2013
Solicitation Topic Code: CBD13-108
Solicitation Number: 2013.1
Small Business Information
Radiation Monitoring Devices, Inc.
MA, Watertown, MA, 02472-4699
DUNS: 073804411
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Richard Myers
 Principla Investigator
 (617) 668-6800
 RMyers@RMDInc.com
Business Contact
 Joanne Gladstone
Title: Vice President
Phone: (617) 668-6800
Email: JGladstone@RMDInc.com
Research Institution
 Stub
Abstract
In the event of an intentional or accidental release of ionizing radiation, it will be critical to have rapid triage assessment tools to evaluate the health of mission-critical personnel and to make effective use of available medical and emergency resources. However, assessment of whole body radiation dosage is challenging and established methods rely on visual manifestations, blood sampling and sophisticated laboratory tests that require multiple days for accurate analysis. To overcome the challenges of measuring whole body radiation exposure, Radiation Monitoring Devices, Inc. (RMD) will seek to design and assemble a field-ready biodosimeter for triage assessment of warfighters based on a simple optical method. The instrument will utilize the physiological changes caused by radiation injury as biomarkers for assessing whole-body exposure. In combination with data analysis, it offers the promise of rapid and non-invasive screening of large, diverse populations. The exploratory research performed under this grant will validate the dose assessment at time points less than 24 hours following controlled gamma-ray radiation exposure in living rat models. Information from these studies will be used to guide the design of a field-ready instrument for consistent and real-time whole body ionizing radiation dose measurements in humans.

* information listed above is at the time of submission.

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