Biosensor and Controller for Closed Loop Anesthesia Delivery System

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$149,984.00
Award Year:
2013
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-13-C-0099
Agency Tracking Number:
H122-012-0163
Solicitation Year:
2012
Solicitation Topic Code:
DHP12-012
Solicitation Number:
2012.2
Small Business Information
Infusense
6415 River Tide Drive, Memphis, TN, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
024061303
Principal Investigator:
Chuck Witkowski
Princiap Investigator
(865) 566-3912
Chuck.Witkowski@gmail.com
Business Contact:
Edward Chaum
Founder, Chief Medical Officer
(901) 494-3140
echaum@infusense.com
Research Institution:
Stub




Abstract
Microfabricated chemical and biological sensors serve as an interface between biologic and electronic systems. Previously, through TATRC-funded research grants (W81XWH-05-2-0064, W81XWH-10-1-0358), we have investigated the behavior and detection of propofol using electrochemical (EC) methods. Using these analytical methods, we have quantified the oxidation of propofol well below therapeutic concentrations in reagents and in serum, and have designed and fabricated several prototype biosensors using; 1) carbon fiber microdisc electrodes, 2) carbon nanofiber electrodes, and 3) organic membrane-coated carbon electrodes. We have previously tested and reported on sensor performance, signal sensitivity and stability, biofouling, and biological interference ex vivo to model clinical performance and validated sensor performance in pilot clinical studies. We have also developed a prototype preclinical platform feedback control loop (including controller design elements) for closed-loop infusional propofol anesthesia to automate drug delivery in real-time in vivo, using small infusion systems. The goal of this Phase I SBIR is to integrate our biosensor prototypes and EC methods with current TCI pump technology and complete controller design testing of the small platform closed loop device to deliver real time (<1 second) sensing of propofol levels.

* information listed above is at the time of submission.

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