Nano-Therapeutics for Peripheral Neuropathy

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: W81XWH-13-C-0014
Agency Tracking Number: H122-013-0100
Amount: $149,927.00
Phase: Phase I
Program: SBIR
Awards Year: 2013
Solicitation Year: 2012
Solicitation Topic Code: DHP12-013
Solicitation Number: 2012.2
Small Business Information
Photonic Systems Division, 1845 W. 205th Street, Torrance, CA, -
DUNS: 153865951
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Gregory Zeltser
 Principal Scientist
 (310) 320-3088
Business Contact
 Gordon Drew
Title: Chief Financial Officer
Phone: (310) 320-3088
Research Institution
To address the DHP need for a controlled, target-specific delivery system for topical treatment of peripheral neuropathy (PN), Physical Optics Corporation (POC) proposes to develop Nano Therapeutics for Peripheral Neuropathy (NATPEN). The NATPEN will include a nanocarrier (NC) loaded with specific drugs, a biocompatible gel to contain the NC, and a microneedle patch for transdermal delivery of the therapeutic. The innovations in the NATPEN as a topical treatment modality will enable minimally invasive, extended, targeted delivery of drugs to the peripheral terminals of the sensory neurons. The NATPEN modality has minimal toxicity and is easy to administer. In Phase I, POC will demonstrate the feasibility of the NATPEN concept by developing a prototype of a topical drug delivery system capable of transporting the therapeutic through skin and having nerve targeting capability and controlled release of the drug. In Phase II, POC plans to optimize, demonstrate, and validate the therapeutic modality in animal models of PN. The FDA approval pathway will be outlined and considered at each developmental stage.

* Information listed above is at the time of submission. *

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