Encapsulation Technology for Increased Environmental Stability of Vertebrate Cells

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$99,999.00
Award Year:
2013
Program:
SBIR
Phase:
Phase I
Contract:
W9132T-13-C-0004
Award Id:
n/a
Agency Tracking Number:
A122-090-0468
Solicitation Year:
2012
Solicitation Topic Code:
A12-090
Solicitation Number:
2012.2
Small Business Information
1 Riverside Circle, Suite 400, Roanoke, VA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
627132913
Principal Investigator:
Blaine Butler
Principal Investigator
(434) 220-2509
butlerb@lunainnovations.com
Business Contact:
Shirley Evans
Sr. Contract Administrator
(540) 961-6724
submissions302@lunainnovations.com
Research Institute:
Stub




Abstract
Luna Innovations is developing stabilization technology for increased long-term storage of various biological moieties (e.g. enzymes, nucleic acids, and whole cells). This unique stabilization matrix allows for extended cell viability lifetime, minimizing cell maintenancerequirements while retaining physiological activity. The proposed encapsulated cell technology will provide significant improvements in cell lifetime, operational stability, with decreased maintenance requirements, and is easily integrated into a variety of sensing based platforms allowing for optical and/or electrical reporting metrics. During Phase I Luna will demonstrate stable long-term cell viability with enhanced environmental stability for a variety of cell lines (including mammalian cells) for a minimum of 8 weeks while still retaining physiological cellular activity. Phase II will focus on extending the cell viability and function to a minimum of 6 months for an increased variety of cell types while also working to integrate the stabilization technology into a microfluidic chip for incorporation into the SafePort water analysis system.

* information listed above is at the time of submission.

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