Origami Antibodies for Threat Sensing

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-13-C-0016
Agency Tracking Number: A2-5049
Amount: $465,948.00
Phase: Phase II
Program: STTR
Awards Year: 2013
Solicitation Year: 2011
Solicitation Topic Code: A11a-T021
Solicitation Number: 2011.A
Small Business Information
11260 Roger Bacon Drive, Suite 406, Reston, VA, -
DUNS: 828881305
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Michael Norton
 (304) 696-6627
Business Contact
 Paula Gawthorp-Armentrout
Title: Corporate Officer
Phone: (703) 689-9689
Email: parmentrout@parabon.com
Research Institution
 Marshall University
 Janice Morgan
 401 11th Street, Suite 1400
Huntington, WV, 25701-
 (304) 696-2468
 Nonprofit college or university
Beginning from an advanced stage of development, this Phase II STTR project will produce designs and prototypes for a ricin-specific artificial antibody constructed using DNA origami. These novel constructs will provide both a capture function (mimicking the properties of an antibody) and intrinsic optical reporting functionality, which marks a significant improvement over current antibody capability. Accordingly, they will prove a compelling substitute for antibodies in a wide variety of applications, beginning with ELISA-like laboratory tests, evolving to rapid, fieldable Lateral Flow Immunoassay tests for threat sensing, and will be generalizable to all current antibody applications. Phase II includes two experimental thrusts. The first involves the optimization of the synthetic constructs designed in Phase I to capture and report optically the threat agent ricin. The second involves manufacturability, a focus on issues which must be surmounted for DNA-based systems to become large-scale commodities and system components. These efforts will lead to enhancements to Parabon"s existing origami design automation software, specifically for the creation of artificial antibodies. Such enhancements are essential for computing optimal placement of capture and response elements, and displaying surface charge and relative hydrophobicity profiles.

* Information listed above is at the time of submission. *

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