Origami Antibodies for Threat Sensing

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$465,948.00
Award Year:
2013
Program:
STTR
Phase:
Phase II
Contract:
W911NF-13-C-0016
Award Id:
n/a
Agency Tracking Number:
A2-5049
Solicitation Year:
2011
Solicitation Topic Code:
A11a-T021
Solicitation Number:
2011.A
Small Business Information
11260 Roger Bacon Drive, Suite 406, Reston, VA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
828881305
Principal Investigator:
Michael Norton
Professor
(304) 696-6627
Norton@Marshall.edu
Business Contact:
Paula Gawthorp-Armentrout
Corporate Officer
(703) 689-9689
parmentrout@parabon.com
Research Institute:
Marshall University
Janice Morgan
401 11th Street, Suite 1400
Huntington, WV, 25701-
(304) 696-2468
Nonprofit college or university
Abstract
Beginning from an advanced stage of development, this Phase II STTR project will produce designs and prototypes for a ricin-specific artificial antibody constructed using DNA origami. These novel constructs will provide both a capture function (mimicking the properties of an antibody) and intrinsic optical reporting functionality, which marks a significant improvement over current antibody capability. Accordingly, they will prove a compelling substitute for antibodies in a wide variety of applications, beginning with ELISA-like laboratory tests, evolving to rapid, fieldable Lateral Flow Immunoassay tests for threat sensing, and will be generalizable to all current antibody applications. Phase II includes two experimental thrusts. The first involves the optimization of the synthetic constructs designed in Phase I to capture and report optically the threat agent ricin. The second involves manufacturability, a focus on issues which must be surmounted for DNA-based systems to become large-scale commodities and system components. These efforts will lead to enhancements to Parabon"s existing origami design automation software, specifically for the creation of artificial antibodies. Such enhancements are essential for computing optimal placement of capture and response elements, and displaying surface charge and relative hydrophobicity profiles.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government