High-resolution optical imaging and spectroscopy instrument for real-time characterization of soft tissue constructs

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$999,793.00
Award Year:
2013
Program:
SBIR
Phase:
Phase II
Contract:
W81XWH-12-C-0075
Award Id:
n/a
Agency Tracking Number:
O2-1326
Solicitation Year:
2011
Solicitation Topic Code:
OSD11-H08
Solicitation Number:
2011.2
Small Business Information
MA, Andover, MA, 01810-1077
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
073800062
Principal Investigator:
Nicusor Iftimia
Principal Research Scient
(978) 738-8192
iftimia@psicorp.com
Business Contact:
B. Green
President and CEO
(978) 689-0003
green@psicorp.com
Research Institution:
Stub




Abstract
Traumatic injuries, especially in the combat setting, are often associated with significant tissue loss and morbidity. Immediate reconstruction is often needed to prevent further morbidity and degradation of soldier health status. Novel regenerative medicine approaches, including grafting of engineered tissue have the potential to address this problem. However, the absence of adequate tools for testing tissue morphology and viability before grafting makes this process very difficult. Thus, there is an urgent need for a technology that will enable real time, noninvasive, three-dimensional quantitative assessment of growing ex vivo engineered tissue to assess cell state and viability, microstructure, and overall tissue state and maturity for transplantation. In a Phase I study, Physical Sciences Inc. (PSI) in collaboration with the Center for Regenerative Medicine at the Massachusetts General Hospital (MGH), investigated the use of combined Raman spectroscopy-high resolution optical imaging for in vitro characterization of engineered tissue constructs. The Phase I study has successfully demonstrated the suitability of this approach for nondestructive characterization of tissue constructs. As a result, an advanced instrument, suitable for research use at MGH, Center for Regenerative Medicine is proposed to be developed and fully evaluated in a Phase II study.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government