Chimeric Autologous/Allogeneic Constructs for Skin Regeneration

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$999,934.00
Award Year:
2013
Program:
SBIR
Phase:
Phase II
Contract:
W81XWH-12-C-0063
Award Id:
n/a
Agency Tracking Number:
O2-1328
Solicitation Year:
2011
Solicitation Topic Code:
OSD11-H10
Solicitation Number:
2011.2
Small Business Information
505 S. Rosa Road, Suite 169, Madison, WI, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
160392168
Principal Investigator:
Cathy Rasmussen
Senior Scientist
(608) 441-2748
crasmussen@stratatechcorp.com
Business Contact:
Robert Barnard
Vice President&Treasure
(608) 441-2756
rbarnard@stratatechcorp.com
Research Institution:
Stub




Abstract
Complex skin defects, including burns and trauma, represent a major medical problem affecting both military and civilian populations. In recent military engagements, burns account for approximately 5% of combat casualties. Furthermore, approximately 1.25 million Americans each year require medical attention for complex skin defects, with 50,000 people hospitalized for burns and 13,000 requiring skin grafts. With severe skin injuries and extensive burns, skin loss must be addressed promptly to prevent life-threatening complications. However, restoration of fully-functional skin requires regeneration of the interfollicular epidermis, the cutaneous appendages, and the underlying vascularized dermis. Currently, no therapeutic approach addresses both the immediate need for wound coverage and the ultimate goal of autologous skin tissue regeneration with functional restoration. To address this unmet need, we propose to combine technologies already in development to provide an innovative alternative approach to the traditional standard of care. The proposed therapeutic approach combines the advantages of a next generation bioengineered skin substitute with the benefits of autologous tissue micrografting to 1) recapitulate the normal barrier function of intact human skin, 2) reduce time to wound closure, 3) speed wound revascularization, and 4) deliver autologous tissue for skin regeneration with functional and cosmetic restoration.

* information listed above is at the time of submission.

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