Chimeric Autologous/Allogeneic Constructs for Skin Regeneration

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: W81XWH-12-C-0063
Agency Tracking Number: O2-1328
Amount: $999,934.00
Phase: Phase II
Program: SBIR
Awards Year: 2013
Solicitation Year: 2011
Solicitation Topic Code: OSD11-H10
Solicitation Number: 2011.2
Small Business Information
505 S. Rosa Road, Suite 169, Madison, WI, -
DUNS: 160392168
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Cathy Rasmussen
 Senior Scientist
 (608) 441-2748
Business Contact
 Robert Barnard
Title: Vice President&Treasure
Phone: (608) 441-2756
Research Institution
Complex skin defects, including burns and trauma, represent a major medical problem affecting both military and civilian populations. In recent military engagements, burns account for approximately 5% of combat casualties. Furthermore, approximately 1.25 million Americans each year require medical attention for complex skin defects, with 50,000 people hospitalized for burns and 13,000 requiring skin grafts. With severe skin injuries and extensive burns, skin loss must be addressed promptly to prevent life-threatening complications. However, restoration of fully-functional skin requires regeneration of the interfollicular epidermis, the cutaneous appendages, and the underlying vascularized dermis. Currently, no therapeutic approach addresses both the immediate need for wound coverage and the ultimate goal of autologous skin tissue regeneration with functional restoration. To address this unmet need, we propose to combine technologies already in development to provide an innovative alternative approach to the traditional standard of care. The proposed therapeutic approach combines the advantages of a next generation bioengineered skin substitute with the benefits of autologous tissue micrografting to 1) recapitulate the normal barrier function of intact human skin, 2) reduce time to wound closure, 3) speed wound revascularization, and 4) deliver autologous tissue for skin regeneration with functional and cosmetic restoration.

* Information listed above is at the time of submission. *

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