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Investigation of CytoSorb cytokine and myoglobin removal in the treatment of trauma and burn injury

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-12-C-0038
Agency Tracking Number: A2-5174
Amount: $1,246,262.12
Phase: Phase II
Program: SBIR
Solicitation Topic Code: A11-105
Solicitation Number: 11.2
Solicitation Year: 2011
Award Year: 2012
Award Start Date (Proposal Award Date): 2012-09-25
Award End Date (Contract End Date): 2017-10-07
Small Business Information
7 Deer Park Drive, Suite K
Monmouth Junction, NJ 08852
United States
DUNS: 830014077
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Phillip Chan
 (732) 329-8885
Business Contact
 James Cason
Phone: (732) 398-5427
Research Institution

Trauma and burn injuries are leading causes of military casualties and need more effective treatments. They are frequently associated with a severe systemic inflammatory response syndrome, triggered by tissue damage, cytokine and inflammatory mediator release, ischemia-reperfusion injury, and others, as well as complications such as hemorrhage and rhabdomyolysis that can cause multiple organ dysfunction syndrome (MODS) and multi-organ failure (MOF). Organ failure significantly increases the risk of morbidity and mortality in wounded warfighters. Despite this, there have been few advances in treating these underlying causes of organ injury. In this Phase II SBIR proposal, CytoSorbents plans to demonstrate the broad utility of blood purification, using an advanced, biocompatible, porous polymer sorbent, to prevent or treat organ failure in both trauma and burn injury. Building upon work accomplished in Phase I, CytoSorbents will test a portable, robust, and logistically-friendly blood purification system that combines a state-of-the-art battery-powered blood pump with CytoSorbents’ sorbent bead technology, that can be easily stockpiled and used in far-forward medical facilities. This blood purification system will be tested in two porcine models of trauma/rhabdomyolysis and burn/inhalation injury to reduce excessive cytokines, myoglobin and other inflammatory mediators in blood, with the goal of preventing or treating organ failure.

* Information listed above is at the time of submission. *

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