Effective New Topical Treatment to Reduce Scar Formation in Burns

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$149,904.00
Award Year:
2013
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-13-C-0053
Award Id:
n/a
Agency Tracking Number:
H122-016-0254
Solicitation Year:
2012
Solicitation Topic Code:
DHP12-016
Solicitation Number:
2012.2
Small Business Information
1420 N. Claremont Blvd, Suite 105D, Claremont, CA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
830276353
Principal Investigator:
ShendaBaker
President
(909) 447-6858
sb@synedgen.com
Business Contact:
ChristopherRyan
Associate Director
(909) 447-6858
cr@synedgen.com
Research Institute:
n/a
Abstract
Thermal injury is common in military conflicts due to primarily to the widespread use of explosive devices. Burns can produce scars that are excessive, physically debilitating and functionally damaging. There is a critical need for an effective product that can control bacterial contamination and prevent colonization, mitigate inflammation, and diffuse to or reach necrotic and damaged tissue resulting from a blast or traumatic thermal wound to reduce the formation of fibrotic scars. Synedgen has developed a biocompatible polysaccharide derivative (PAAG) that has been demonstrated in vivo and in vitro to reduce inflammation and provide enhanced healing with the reduction of scarring. This Phase 1 study will demonstrate the extent to which PAAG mitigates scar reduction in full thickness burns in a porcine model, and provide an opportunity to examine innate immune responses, inflammatory cytokines and healing pathways.

* information listed above is at the time of submission.

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