Development of a hand-held, field-deployable multiplex assay for the detection of Chikungunya Virus (CHIKV), West Nile Virus (WNV), and Dengue Virus i

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-10-C-0181
Agency Tracking Number: O093-H20-3139
Amount: $99,665.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solitcitation Year: 2009
Solitcitation Topic Code: OSD09-H20
Solitcitation Number: 2009.3
Small Business Information
InBios International
562 1st Ave S, Suite 600, Seattle, WA, 98104
Duns: 004006628
Hubzone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Raymond Houghton
 Director New Product Development
 (206) 344-5821
Business Contact
 Estela Raychaudhuri
Title: President
Phone: (206) 344-5821
Research Institution
Chikungunya an alphavirus, and the West Nile and Dengue Flaviviruses are carried by mosquitoes. While all three initially lead to febrile illness the subsequent clinical outcomes are very different and in some cases dual infections can occur. All three viruses have the potential to lead to fatal outcomes. Knowledge of the particular viruses carried by mosquitoes in areas of troop deployment would lead to improved and potentially early intervention in military personnel presenting with febrile illness. The purpose of this proposal is to develop a Multiline Lateral flow Immunoassay that would be field deployable and capable of independently detecting the presence of Chikungunya, Dengue or West Nile Viruses directly in mosquitoes. The test would be based on the use of specific antibodies to viral antigens in capture immunoassays. It is anticipated the test will use a colloidal gold detection system. The test will be designed to be stable and field deployable. The availability of such a test would have both military applications in many troop deployment areas as well as utility by epidemiologists in countries where these viral diseases are prevalent.

* information listed above is at the time of submission.

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