Developing a Point-of-Care Diagnostic Assay for Leptospirosis

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-10-C-0017
Agency Tracking Number: A092-105-0170
Amount: $118,443.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2009
Solicitation Topic Code: A09-105
Solicitation Number: 2009.2
Small Business Information
InBios International
562 1st Ave S, Suite 600, Seattle, WA, 98104
DUNS: 004006628
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Stan Morkowski
 President
 (206) 344-5823
 stan@inbios.com
Business Contact
 Estela Raychaudhuri
Title: Senior Scientist
Phone: (206) 344-5821
Email: inbios@aol.com
Research Institution
N/A
Abstract
The objective of this study is to develop a robust, field deployable, and a cost effective rapid screening assay for the detection of Leptospirosis infection caused by Leptospira pathogens using human blood and sera. The test will utilize a lateral flow based immunochromatographic system (dipstick). The proposed assay would be very useful screening tool to assess leptospirosis infection in the fields, in remote areas, and on how complexity situation. Such a test would facilitate diagnosis and treatment for military personnel presenting febrile illness. A rapid assay would also help in Leptospirosis eradication programs. In this Phase I study we will develop/acquire antibody and antigen reagents for use in development of prototype Leptospirosis detection assays. We will then construct prototype assay that will be evaluated using archived samples from infected individuals. Further development of the assay would take place in a phase II proposal

* information listed above is at the time of submission.

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