lmmunonanoparticle Optical Sensor for CTC Detection

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N43CO201000050
Agency Tracking Number: N43CO201000050
Amount: $200,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: NCI
Solicitation Number: PHS2010-1
Small Business Information
INNOSENSE, LLC
2531 W 237TH ST, STE 127, TORRANCE, CA, 90505-
DUNS: 114060861
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Tania Betancourt
Business Contact
Phone: (310) 530-2011
Email: kisholoy.goswami@innosense.us
Research Institution
N/A
Abstract
Cancer remains one of the most prevalent diseases to date. Detection of circulating tumor cells (CTCs) in the vasculature has been identified as a promising method for determination of cancer risk, cancer prognosis, and determination of the effect of therapy. This proposal aims to establish the feasibility of a system for optical detection of CTCs that could be used in a point-of-care setting. Nanoparticles doped with near-infrared fluorophores and with high affinity to the cancer cells will be utilized for tagging CTCs in blood samples. The nanoparticles will provide high signal amplification for ultrasensitive detection. Phase I will focus on the evaluation of the diagnostic setup using body fluids spiked with CTCs. Phase II will develop a prototype and optimize the system for detection of patient samples. This project is expected to result in a small and rapid sensor that could be used at a physician's office or at small diagnostic laboratories, and which could become essential for the diagnosis and management of cancer patients.

* information listed above is at the time of submission.

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