lmmunonanoparticle Optical Sensor for CTC Detection

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$200,000.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
N43CO201000050
Award Id:
96065
Agency Tracking Number:
N43CO201000050
Solicitation Year:
n/a
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
2531 W 237TH ST, STE 127, TORRANCE, CA, 90505-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
114060861
Principal Investigator:
TANIA BETANCOURT
Business Contact:
(310) 530-2011
kisholoy.goswami@innosense.us
Research Institution:
n/a
Abstract

'Cancer remains one of the most prevalent diseases to date. Detection of circulating tumor cells (CTCs) in the vasculature has been identified as a promising method for determination of cancer risk, cancer prognosis, and determination of the effect of therapy. This proposal aims to establish the feasibility of a system for optical detection of CTCs that could be used in a point-of-care setting. Nanoparticles doped with near-infrared fluorophores and with high affinity to the cancer cells will be utilized for tagging CTCs in blood samples. The nanoparticles will provide high signal amplification for ultrasensitive detection. Phase I will focus on the evaluation of the diagnostic setup using body fluids spiked with CTCs. Phase II will develop a prototype and optimize the system for detection of patient samples. This project is expected to result in a small and rapid sensor that could be used at a physician's office or at small diagnostic laboratories, and which could become essential for the diagnosis and management of cancer patients.

* information listed above is at the time of submission.

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