Replicon Particle Vaccine for White Spot Syndrome Virus in Marine Shrimp

Award Information
Agency:
Department of Agriculture
Branch
n/a
Amount:
$79,700.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
99210
Agency Tracking Number:
2010-00150
Solicitation Year:
n/a
Solicitation Topic Code:
8.7
Solicitation Number:
n/a
Small Business Information
2325 N LOOP DR, Ames, IA, 50010
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
021642490
Principal Investigator:
Kurt Kamrud
null
(919) 909-1726
kurt.sirrah@gmail.com
Business Contact:
Kurt Kamrud
null
(919) 909-1726
kurt.sirrah@gmail.com
Research Institution:
n/a
Abstract
WSSV is the most serious disease in farmed marine shrimp causing considerable financial losses throughout the last decade across the globe. It infects a wide variety of crustacean hosts including numerous species of wild and cultured marine shrimp, crayfish, and prawns. Although a multitude of vaccination strategies have been attempted with mixed results, no viable commercial product exists on the market. Our preliminary data demonstrate that Alphavirus replicon particles (RP) and a Sindbis (SIN) virus vector infect and express green fluorescent protein in shrimp following injection. Evidence also exists in other invertebrates that oral exposure through immersion has been a successful challenge model with other Alphaviruses. It is proposed that utilizing alphaviruses or alphavirus replicon particles would provide an effective platform for gene expression for mass WSSV vaccination of farmed shrimp.

* information listed above is at the time of submission.

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