MULTIFUNCTIONAL NANOJACKETS FOR BREAST CANCER TREATMENT

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$198,510.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
N43CO201000045
Agency Tracking Number:
N43CO201000045
Solicitation Year:
n/a
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
KEYSTONE NANO, INC.
1981 Pine Hall Road, STATE COLLEGE, PA, 16801-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
610435070
Principal Investigator:
MYLISA PARETTE
(814) 863-8735
mparette@keystonenano.com
Business Contact:
(814) 237-4657
jdavidson@keystonenano.com
Research Institution:
n/a
Abstract

'Keystone Nano, building on a successful partnership with Nalco and co-development programs with Johnson and Johnson, Eli Lilly, United Therapeutics, NanoTherapies, and the NCI, will develop multifunctional calcium phosphate NanoJackets for the simultaneous diagnosis and treatment of breast cancer. Despite advances in detection and treatment, breast cancer is still the second most common cancer among women with the chance of a woman developing breast cancer during her lifetime at an estimated 12% and over 40,000 women dying from breast cancer each year (ACS). The development of NanoJackets containing both Indocyanine Green, a FDA-approved near infrared fluorophore, for fluorescent imaging based diagnosis, as well as siRNA directed against a mutation in the PI3K gene, which occurs in approximately 25% of breast  cancers, will result in a multifunctional nanoparticulate pharmaceutical that can simultaneously image and treat breast cancer. The objectives of this Phase I project are to demonstrate reproducible manufacturing of  ICG-PI3KCA siRNA NanoJackets as well as in vitro and in vivo diagnostic and therapeutic efficacy for human breast cancer. If successful, these data will lay the groundwork for further development of targeted  ICG-PI3KCA siRNA NanoJackets and provide the basis for an array of theranostic NanoJacket products for a variety of cancers.

* information listed above is at the time of submission.

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