MULTIFUNCTIONAL NANOJACKETS FOR BREAST CANCER TREATMENT

Award Information
Agency:
Department of Health and Human Services
Amount:
$198,510.00
Program:
SBIR
Contract:
N43CO201000045
Solitcitation Year:
2010
Solicitation Number:
PHS2010-1
Branch:
N/A
Award Year:
2010
Phase:
Phase I
Agency Tracking Number:
N43CO201000045
Solicitation Topic Code:
NCI
Small Business Information
KEYSTONE NANO, INC.
1981 Pine Hall Road, STATE COLLEGE, PA, 16801-
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
610435070
Principal Investigator
 Mylisa Parette
 (814) 863-8735
 mparette@keystonenano.com
Business Contact
Phone: (814) 237-4657
Email: jdavidson@keystonenano.com
Research Institution
N/A
Abstract
Keystone Nano, building on a successful partnership with Nalco and co-development programs with Johnson and Johnson, Eli Lilly, United Therapeutics, NanoTherapies, and the NCI, will develop multifunctional calcium phosphate NanoJackets for the simultaneous diagnosis and treatment of breast cancer. Despite advances in detection and treatment, breast cancer is still the second most common cancer among women with the chance of a woman developing breast cancer during her lifetime at an estimated 12% and over 40,000 women dying from breast cancer each year (ACS). The development of NanoJackets containing both Indocyanine Green, a FDA-approved near infrared fluorophore, for fluorescent imaging based diagnosis, as well as siRNA directed against a mutation in the PI3K gene, which occurs in approximately 25% of breast cancers, will result in a multifunctional nanoparticulate pharmaceutical that can simultaneously image and treat breast cancer. The objectives of this Phase I project are to demonstrate reproducible manufacturing of ICG-PI3KCA siRNA NanoJackets as well as in vitro and in vivo diagnostic and therapeutic efficacy for human breast cancer. If successful, these data will lay the groundwork for further development of targeted ICG-PI3KCA siRNA NanoJackets and provide the basis for an array of theranostic NanoJacket products for a variety of cancers.

* information listed above is at the time of submission.

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