SBIR Phase II:Plasma Thermograms for Disease Detection and Monitoring

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 1026824
Agency Tracking Number: 0912660
Amount: $499,826.00
Phase: Phase II
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: BC
Solicitation Number: NSF 08-548
Small Business Information
400 W Market St, Ste 1800, Louisville, KY, 40202
DUNS: 825146975
HUBZone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Greg Brewood
 (503) 725-2350
Business Contact
 Greg Brewood
Phone: (503) 725-2350
Research Institution
This Small Business Innovation Research (SBIR) Phase II project will develop a powerful new diagnostic assay platform that will form the basis of a novel high-throughput diagnostic assay for detection and differential diagnosis of six autoimmune diseases: Lupus, Rheumatoid Arthritis, Multiple Sclerosis, Scleroderma, Polymyositis, and Lyme disease. Assay output is a differential scanning calorimetry (DSC) thermogram that is a characteristic signature for an individual's plasma or serum. The characteristic pattern provides a quantitative measure of the manifold components comprising an individual's plasma/serum, thereby providing an entirely new metric with which to analyze the fluids. The goal is completion of the necessary R&D objectives required to build a prototype diagnostic assay based on the plasma thermogram technology platform. Activities and experiments are directed at automating and optimizing laboratory assay capabilities; defining essential assay parameters and quantitative metrics; and testing and validating the prototype assay. The broader impact/commercial potential of this project is the radical alteration of treatment paradigms, improved patient outcomes and reduced costs of patient care for complex diseases like autoimmune diseases. As many as 24 million people in the USA are affected by autoimmune disease. Convenient, quantitative and cost-effective diagnoses for numerous diseases, including targeted autoimmune diseases are not readily available. Early differential diagnosis between these diseases is an important unmet medical need and critical for timely and accurate treatment of disease and its complications. In addition, early accurate diagnosis potentially mitigates the costs and inconvenience associated with redundant administration of the current immunological, serological, clinical and pathological tests. Thus, a non-invasive blood assay like the plasma thermogram test that can differentially diagnose autoimmune diseases will be highly beneficial. The company will establish a CLIA (Clinical Laboratories Improvement Act) laboratory from which to market and sell the plasma thermogram test. A central laboratory offers a fast, low cost and high revenue business model for introducing new diagnostic tests into the marketplace. Commercialization of the thermogram technology platform represents a potential multi-million dollar market opportunity.

* Information listed above is at the time of submission. *

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