MULTIFUNCTIONAL SIRNA NANOPARTICLES FOR AML THERAPY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$200,000.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
N43CO201000051
Award Id:
96066
Agency Tracking Number:
N43CO201000051
Solicitation Year:
n/a
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
1109 MILLCREEK LN, COLUMBUS, OH, 43220-4949
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
167239057
Principal Investigator:
XIAOJUANYANG
Business Contact:
(614) 442-1231
lienyu4675@yahoo.com
Research Institute:
n/a
Abstract

'This project will investigate transferrin (Tf) conjugated fluorescent nanoparticles loaded with an siRNA, LOR-1284, as a theranostic agent for acute myelogenous leukemia (AML). LOR-1284, a siRNA targeting the R2 subunit of ribonucleotide reductase (RNR), is a promising agent for overcoming RNR-mediated drug resistance in AML. The nanoparticles are designed to facilitate LOR-1284 delivery to AML cells (for therapy) while enabling easy detection of delivery efficiency to the AML cells in leukemia patients (for diagnosis). A novel microfluidic method has been developed for nanoparticle synthesis. This project will be carried out by a multidisciplinary team of investigators at NIL and at The Ohio State University.

* information listed above is at the time of submission.

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