MULTIFUNCTIONAL SIRNA NANOPARTICLES FOR AML THERAPY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$200,000.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
N43CO201000051
Agency Tracking Number:
N43CO201000051
Solicitation Year:
2010
Solicitation Topic Code:
NCI
Solicitation Number:
PHS2010-1
Small Business Information
NANOMATERIAL INNOVATION, LTD
1109 MILLCREEK LN, COLUMBUS, OH, 43220-4949
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
Y
Duns:
167239057
Principal Investigator:
Xiaojuan Yang
Business Contact:
(614) 442-1231
lienyu4675@yahoo.com
Research Institution:
n/a
Abstract
This project will investigate transferrin (Tf) conjugated fluorescent nanoparticles loaded with an siRNA, LOR-1284, as a theranostic agent for acute myelogenous leukemia (AML). LOR-1284, a siRNA targeting the R2 subunit of ribonucleotide reductase (RNR), is a promising agent for overcoming RNR-mediated drug resistance in AML. The nanoparticles are designed to facilitate LOR-1284 delivery to AML cells (for therapy) while enabling easy detection of delivery efficiency to the AML cells in leukemia patients (for diagnosis). A novel microfluidic method has been developed for nanoparticle synthesis. This project will be carried out by a multidisciplinary team of investigators at NIL and at The Ohio State University.

* information listed above is at the time of submission.

Agency Micro-sites

US Flag An Official Website of the United States Government