Cloud-computing MapReduce toSearch for Post-Translationally Modified Peptides

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43HG006091-01
Agency Tracking Number: HG006091
Amount: $179,499.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: NHGRI
Solicitation Number: PHS2010-2
Small Business Information
INSILICOS
Insilicos, 111 Queen Anne Ave N., #500, SEATTLE, WA, 98109
DUNS: 126643241
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 ERIK NILSSON
 (206) 979-4832
 ERIKN@INSILICOS.COM
Business Contact
 ERIK NILSSON
Phone: (206) 965-9680
Email: era.commons@insilicos.com
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): A enhancement to the popular peptide search engine X Tandem is proposed, to allow it to run on new super-scalable MapReduce computer clusters. This will allow much faster and less-expensive operation, allowing proteomics researchers to routinely search for post-translational modifications (PTMs). Proteomics has led to many important advances in biological understanding. Yet, many valuable data sets are not searched for PTMs, simply because the computer power necessary to conduct the searches is not available. With this project, we plan to substantially reduce the computational cost of proteomics experiments, via a peptide search engine operating on highly-scalable computer clusters. The research team is well-qualified to undertake this research, having extensive, direct experience in all the scientific disciplines and specific software elements necessary. The research team includes experts in proteomics, mass spectrometry, peptide search, cloud computing, and MapReduce. PUBLIC HEALTH RELEVANCE: High-throughput analysis of post-translational modifications is increasingly pivotal for understanding the molecular function and dynamics of living cells. This proposal thus addresses key opportunities for applying proteomics to human health research.

* information listed above is at the time of submission.

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