Cloud-computing MapReduce toSearch for Post-Translationally Modified Peptides

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$179,499.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
1R43HG006091-01
Award Id:
96290
Agency Tracking Number:
HG006091
Solicitation Year:
n/a
Solicitation Topic Code:
NHGRI
Solicitation Number:
n/a
Small Business Information
Insilicos, 111 Queen Anne Ave N., #500, SEATTLE, WA, 98109
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
126643241
Principal Investigator:
ERIKNILSSON
(206) 979-4832
ERIKN@INSILICOS.COM
Business Contact:
ERIKNILSSON
() -
era.commons@insilicos.com
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): A enhancement to the popular peptide search engine X Tandem is proposed, to allow it to run on new super-scalable MapReduce computer clusters. This will allow much faster and less-expensive operation, allowing proteomic s researchers to routinely search for post-translational modifications (PTMs). Proteomics has led to many important advances in biological understanding. Yet, many valuable data sets are not searched for PTMs, simply because the computer power necessary to conduct the searches is not available. With this project, we plan to substantially reduce the computational cost of proteomics experiments, via a peptide search engine operating on highly-scalable computer clusters. The research team is well-qualified to undertake this research, having extensive, direct experience in all the scientific disciplines and specific software elements necessary. The research team includes experts in proteomics, mass spectrometry, peptide search, cloud computing, and MapReduce. PUBLIC HEALTH RELEVANCE: High-throughput analysis of post-translational modifications is increasingly pivotal for understanding the molecular function and dynamics of living cells. This proposal thus addresses key opportunities for applying proteomics to human health research.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government