Droplet-Based Automation of Complex Workflows for Synthetic Biology

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: D13PC00034
Agency Tracking Number: D12B-003-0017
Amount: $99,713.00
Phase: Phase I
Program: STTR
Awards Year: 2013
Solicitation Year: 2012
Solicitation Topic Code: ST12B-003
Solicitation Number: 2012.B
Small Business Information
615 Davis Drive, Suite 800, Research Triangle Pa, NC, -
DUNS: 140695474
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Brent Lutz
 President and CEO
 (919) 287-9010
Business Contact
 Richard West
Title: President&CEO
Phone: (919) 287-9010
Email: grants@liquid-logic.com
Research Institution
 Stanford University
 Mark Horowitz
 340 Panama Street
Stanford, CA, 94305-
 (650) 725-3707
 Nonprofit college or university
Large-scale genome engineering represents a broad group of technologies, all of which stand to impact the manufacturing of a range of biological and chemical products. While the power of these methods to increase the production of biologically-driven manufacturing processes has been previously demonstrated, they are often developed and optimized toward a single target, or single methodology. Currently, an automation platform does not exist that enables a broad range of genome engineering methods directed towards a diverse range of biomanufactured products. Advanced Liquid Logic (ALL) has developed digital microfluidics, a highly flexible, software programmable liquid handling technology. ALL has demonstrated that this technology is capable of automating a range of bioassay workflows using relatively straightforward device designs and fabrication methods. During this program leaders in genome engineering will be engaged to help identify requirements; technology gaps and potential solutions to enable greater flexibility and capability will be evaluated; and system performance will be analyzed and benchmarked to other methods. The goal of this proposal is to lay the groundwork for the development, in Phase II, of a highly-flexible and less constrained digital microfluidic device, potentially using more advanced fabrication methods, for synthetic biology applications.

* Information listed above is at the time of submission. *

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