Droplet-Based Automation of Complex Workflows for Synthetic Biology

Award Information
Agency:
Department of Defense
Branch
Defense Advanced Research Projects Agency
Amount:
$99,713.00
Award Year:
2013
Program:
STTR
Phase:
Phase I
Contract:
D13PC00034
Award Id:
n/a
Agency Tracking Number:
D12B-003-0017
Solicitation Year:
2012
Solicitation Topic Code:
ST12B-003
Solicitation Number:
2012.B
Small Business Information
615 Davis Drive, Suite 800, Research Triangle Pa, NC, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
140695474
Principal Investigator:
Brent Lutz
President and CEO
(919) 287-9010
mpollack@liquid-logic.com
Business Contact:
Richard West
President&CEO
(919) 287-9010
grants@liquid-logic.com
Research Institute:
Stanford University
Mark Horowitz
340 Panama Street
Stanford, CA, 94305-
(650) 725-3707
Nonprofit college or university
Abstract
Large-scale genome engineering represents a broad group of technologies, all of which stand to impact the manufacturing of a range of biological and chemical products. While the power of these methods to increase the production of biologically-driven manufacturing processes has been previously demonstrated, they are often developed and optimized toward a single target, or single methodology. Currently, an automation platform does not exist that enables a broad range of genome engineering methods directed towards a diverse range of biomanufactured products. Advanced Liquid Logic (ALL) has developed digital microfluidics, a highly flexible, software programmable liquid handling technology. ALL has demonstrated that this technology is capable of automating a range of bioassay workflows using relatively straightforward device designs and fabrication methods. During this program leaders in genome engineering will be engaged to help identify requirements; technology gaps and potential solutions to enable greater flexibility and capability will be evaluated; and system performance will be analyzed and benchmarked to other methods. The goal of this proposal is to lay the groundwork for the development, in Phase II, of a highly-flexible and less constrained digital microfluidic device, potentially using more advanced fabrication methods, for synthetic biology applications.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government