Droplet-Based Automation of Complex Workflows for Synthetic Biology

Award Information
Agency:
Department of Defense
Branch
Defense Advanced Research Projects Agency
Amount:
$99,713.00
Award Year:
2013
Program:
STTR
Phase:
Phase I
Contract:
D13PC00034
Agency Tracking Number:
D12B-003-0017
Solicitation Year:
2012
Solicitation Topic Code:
ST12B-003
Solicitation Number:
2012.B
Small Business Information
Advanced Liquid Logic Inc.
615 Davis Drive, Suite 800, Research Triangle Pa, NC, -
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
140695474
Principal Investigator:
Brent Lutz
President and CEO
(919) 287-9010
mpollack@liquid-logic.com
Business Contact:
Richard West
President&CEO
(919) 287-9010
grants@liquid-logic.com
Research Institution:
Stanford University
Mark Horowitz
340 Panama Street
Stanford, CA, 94305-
(650) 725-3707
Nonprofit college or university
Abstract
Large-scale genome engineering represents a broad group of technologies, all of which stand to impact the manufacturing of a range of biological and chemical products. While the power of these methods to increase the production of biologically-driven manufacturing processes has been previously demonstrated, they are often developed and optimized toward a single target, or single methodology. Currently, an automation platform does not exist that enables a broad range of genome engineering methods directed towards a diverse range of biomanufactured products. Advanced Liquid Logic (ALL) has developed digital microfluidics, a highly flexible, software programmable liquid handling technology. ALL has demonstrated that this technology is capable of automating a range of bioassay workflows using relatively straightforward device designs and fabrication methods. During this program leaders in genome engineering will be engaged to help identify requirements; technology gaps and potential solutions to enable greater flexibility and capability will be evaluated; and system performance will be analyzed and benchmarked to other methods. The goal of this proposal is to lay the groundwork for the development, in Phase II, of a highly-flexible and less constrained digital microfluidic device, potentially using more advanced fabrication methods, for synthetic biology applications.

* information listed above is at the time of submission.

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