Improved Dried Biological Specimen Materials, Recovery and Processing for Diagnostics

Award Information
Agency:
Department of Defense
Branch
Defense Advanced Research Projects Agency
Amount:
$998,795.00
Award Year:
2013
Program:
SBIR
Phase:
Phase II
Contract:
W31P4Q-13-C-0073
Award Id:
n/a
Agency Tracking Number:
D2-1159
Solicitation Year:
2011
Solicitation Topic Code:
SB112-005
Solicitation Number:
2011.2
Small Business Information
696 Amity Road, Route 63, Bethany, CT, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
783630189
Principal Investigator:
Joseph Bango
Principal Investigator
(203) 393-9666
jbango@ctanalytical.com
Business Contact:
Joseph Bango
President
(203) 393-9666
jbango@ctanalytical.com
Research Institute:
n/a
Abstract
The dried blood spot (DBS) method is an alternative to venipuncture. The available data indicates that the DBS method is both precise and accurate for a diverse range of compounds. We discovered that proprietary additives vastly improve extraction of proteins in DBS using electrospray. Our unexpected results appear to dramatically increase analyte recovery concentration while reducing DBS prep, and may have a significant impact on ESI-MS methodology. We are proposing to apply and validate the extraction process over a comprehensive range of clinical panels, validate the test methods for clinical relevance with independent labs, investigate the role of our proprietary additives, and optimize the extraction method with several Universities. Our primary goal is to deliver a final system suitable for implementation into DARPA's ADEPT program. In a possible Phase II Option, we will continue development seeking FDA approval using a CLIA waived approach together with Yale New Haven Hospital's Clinical labs, which will assist in the clinical trials. The proposed program will have the following benefits: a dried analyte capture, storage, and recovery method that can be used by minimally trained individuals that yields CLIA waived clinically accepted tests for analyte panels now routinely reserved for whole blood or serum.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government