Improved Dried Biological Specimen Materials, Recovery and Processing for Diagnostics

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W31P4Q-13-C-0073
Agency Tracking Number: D2-1159
Amount: $1,944,080.24
Phase: Phase II
Program: SBIR
Solicitation Topic Code: SB112-005
Solicitation Number: 2011.2
Timeline
Solicitation Year: 2012
Award Year: 2013
Award Start Date (Proposal Award Date): 2013-02-01
Award End Date (Contract End Date): 2017-03-10
Small Business Information
696 Amity Road Route 63, Route 63, Bethany, CT, 06524
DUNS: 783630189
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Joseph Bango
 Principal Investigator
 (203) 393-9666
 jbango@ctanalytical.com
Business Contact
 Mr. Joseph Bango
Title: President
Phone: (203) 393-9666
Email: jbango@ctanalytical.com
Research Institution
N/A
Abstract
The dried blood spot (DBS) method is an alternative to venipuncture. The available data indicates that the DBS method is both precise and accurate for a diverse range of compounds. We discovered that proprietary additives vastly improve extraction of proteins in DBS using electrospray. Our unexpected results appear to dramatically increase analyte recovery concentration while reducing DBS prep, and may have a significant impact on ESI-MS methodology. We are proposing to apply and validate the extraction process over a comprehensive range of clinical panels, validate the test methods for clinical relevance with independent labs, investigate the role of our proprietary additives, and optimize the extraction method with several Universities. Our primary goal is to deliver a final system suitable for implementation into DARPA's ADEPT program. In a possible Phase II Option, we will continue development seeking FDA approval using a CLIA waived approach together with Yale New Haven Hospitals Clinical labs, which will assist in the clinical trials. The proposed program will have the following benefits: a dried analyte capture, storage, and recovery method that can be used by minimally trained individuals that yields CLIA waived clinically accepted tests for analyte panels now routinely reserved for whole blood or serum.

* Information listed above is at the time of submission. *

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