PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles

Award Information
Agency:
Department of Defense
Branch
Defense Advanced Research Projects Agency
Amount:
$1,000,000.00
Award Year:
2013
Program:
SBIR
Phase:
Phase II
Contract:
W911QX-13-C-0069
Agency Tracking Number:
D2-1196
Solicitation Year:
2012
Solicitation Topic Code:
SB121-003
Solicitation Number:
2012.1
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100, Ithaca, NY, -
Hubzone Owned:
Y
Minority Owned:
Y
Woman Owned:
N
Duns:
022552900
Principal Investigator:
Joel Tabb
Principal Scientist
(607) 272-0002
jtabb@agavebio.com
Business Contact:
Matt Salazar
President
(607) 272-0002
msalazar@agavebio.com
Research Institution:
n/a
Abstract
Wound management becomes increasingly challenging due to bacterial infections, especially from epidemic drug-resistant strains. To address this problem, Agave BioSystems proposes to develop a RANT (Rapidly Adaptable Nanotherapeutics) breadboard system built upon the modules successfully established in Phase I of this work. The proposed breadboard system will use genomic sequencing data generated from wound pathogens to identify unknown pathogens and gene targets. These targets will serve as the basis for design of antisense PNA sequences to be incorporated into a PNA-CPP modified DNA nanoparticle. The pathogen-specific, ad hoc-developed nanoparticles are anticipated to possess characteristics of high efficacy, stability and penetration abilities to facilitate effective and specific elimination of emerging drug resistant microbes.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government