PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W911QX-13-C-0069
Agency Tracking Number: D2-1196
Amount: $1,000,000.00
Phase: Phase II
Program: SBIR
Awards Year: 2013
Solicitation Year: 2012
Solicitation Topic Code: SB121-003
Solicitation Number: 2012.1
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100, Ithaca, NY, -
DUNS: 022552900
HUBZone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 Joel Tabb
 Principal Scientist
 (607) 272-0002
 jtabb@agavebio.com
Business Contact
 Matt Salazar
Title: President
Phone: (607) 272-0002
Email: msalazar@agavebio.com
Research Institution
N/A
Abstract
Wound management becomes increasingly challenging due to bacterial infections, especially from epidemic drug-resistant strains. To address this problem, Agave BioSystems proposes to develop a RANT (Rapidly Adaptable Nanotherapeutics) breadboard system built upon the modules successfully established in Phase I of this work. The proposed breadboard system will use genomic sequencing data generated from wound pathogens to identify unknown pathogens and gene targets. These targets will serve as the basis for design of antisense PNA sequences to be incorporated into a PNA-CPP modified DNA nanoparticle. The pathogen-specific, ad hoc-developed nanoparticles are anticipated to possess characteristics of high efficacy, stability and penetration abilities to facilitate effective and specific elimination of emerging drug resistant microbes.

* information listed above is at the time of submission.

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