Hematopoietic Cell Expansion System

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$520,371.00
Award Year:
1995
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
22187
Agency Tracking Number:
22187
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P. O. BOX 130469, Ann Arbor, MI, 48113
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Douglas R. Armstrong
(313) 936-1773
Business Contact:
() -
Research Institute:
n/a
Abstract
Bone marrow transplant (BMT) is an extraordinarily rapidly growing field, and the number of transplants in the U. S. is expected to grow from a current rate of 15,000 per year to over 100,000 per year by 1995. This rapid expansion is due to the diversity in the types of bone marrow transplantation procedures and the number of clinical procedures that can be benefitted by a BMT. Major limiting factors in BMT therapy is the high cell number that is needed for reingraftment, traumatic procedure needed for cell aspiration, and the poor capability to handle cells ex vivo. Cells are basically frozen during ex vivo storage. Thus, significant need exists for the development of ex vivo hematopoietic cell expansion technologies. We have developed cell culture conditions under which human hematopoietic cells expand ex vivo. Based on this discovery, we wish to develop clinically useful systems to improve BMT procedures. The first step in the development of a clinical-scale system is to make small hematopoietic bioreactor systems that mimic and successfully reproduce the expansive cell culture conditions. We will develop and optimize such a prototype hematopoietic bioreactor system with Phase I funding. If Phase I goals are successfully met, we will pursue a Phase II study to develop clinically useful prototypes.

* information listed above is at the time of submission.

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