Novel Prebiotic Fiber as Targeted Dietary Management of Irritable Bowel Syndrome

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$149,800.00
Award Year:
2013
Program:
SBIR
Phase:
Phase I
Contract:
1R43AA022559-01
Agency Tracking Number:
R43AA022559
Solicitation Year:
2013
Solicitation Topic Code:
NIAAA
Solicitation Number:
PA12-088
Small Business Information
YELLOWSTONE SCIENTIFIC INSTRUMENTS
BOX 160183, 3065 CROW KING RD, BIG SKY, MT, 59716-0183
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
961869562
Principal Investigator
 RICHARD CLARKE
 (406) 995-2535
 clarke@bu.edu
Business Contact
 RICHARD CLARKE
Phone: (406) 995-2535
Email: clarke@bu.edu
Research Institution
 Stub
Abstract
DESCRIPTION: We propose to develop a new type of monitor to directly and simultaneously identify multiple biomarker metabolites in persons suspected of having been exposed to alcohol. The technology we plan to utilize is surface-enhanced Raman scattering(SERS), based on a well-known inelastic laser light scattering analytical technique for precise lab identification of organic compounds. Biomarker detectors and biomarker-based tests must be sensitive, reproducible, affordable, transportable, reliable, andthe samples employed in the detectors must be easy to collect and obtain from serum, plasma, urine, saliva, or other sources. The ideal detection device in both cases is one that is small, portable, easy to use and capable of rapid analysis of multiple biomarkers in a clinical setting, with a minimum of false positives and false negatives to avoid wasting resources and missing actual exposure problems. By detecting the presence of the alcohol biomarkers promptly and at emerging concentrations, the alcoholthreat to tissue and internal organs may be identified early in the exposure cycle, expanding treatment options in the population at risk. The proposed research program seeks to utilize SERS spectroscopy for rapid at-site blood, urine or saliva analysis for multiple biomarkers in a single, field-deployable device, bringing the power of the Raman technique in a practical, cost-effective configuration to at-site clinical analysis. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: The proposed research program seeks to utilize vibrational spectroscopy for rapid at-site blood, urine or saliva analysis for multiple alcohol biomarkers in a practical, cost-effective monitor suitable for at-site clinical analysis. By detecting the presenceof the alcoholbiomarkers promptly and at emerging concentrations, the alcohol threat to tissue and internal organs may be identified early in the exposure cycle, expanding treatment options in the population at risk.

* information listed above is at the time of submission.

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