Integrin Targeted Therapy for the Treatment of Ovarian Cancer

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43DA037588-01A1
Agency Tracking Number: R43DA037588
Amount: $234,295.00
Phase: Phase I
Program: SBIR
Awards Year: 2013
Solicitation Year: 2013
Solicitation Topic Code: NIDA
Solicitation Number: PA13-088
Small Business Information
DUNS: 144815151
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (971) 222-6550
Business Contact
Phone: (503) 707-1291
Research Institution
Summary Sleep disordered breathing (SDB) is believed to be a widespread, under-diagnosed condition associated with detrimental health problems, at a high cost to society. The current gold standard for diagnosis of SDB is a time- consuming, expensive, and obtrusive (requiring many attached wires) sleep study, or polysomnography (PSG). The immediate objective of the proposed research is to develop and evaluate a hardware design and a set of algorithms for automatically detecting obstructive, central, or mixedapneas and hypopneas from acoustic, peripheral oxygen saturation (SpO2), and pulse rate data, using an ambient microphone and a wireless pulse oximeter. The long-term goal is to create a low-cost, easy-to-operate, minimally obtrusive, at-home device thatcan be used to screen for SDB in patients' homes. Our specific aims are to: (1) develop a screening system by selecting minimally obtrusive sensor hardware and extending state-of-the art algorithms for automatically detecting SDB from acoustic, SpO2, andpulse rate data; (2) collect patient data in the sleep lab and at home from representative populations using the proposed system; (3) determine the screening accuracy by comparing the performance of the proposed system on the collected data against standard PSG-derived clinical results; and (4) measure the usability of an at-home screening device by the target population, by asking subjects who participated in the at-home data collection to complete a survey on various aspects of the setup and operation ofthe proposed system. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: The proposed work will create a portable, low-cost, and minimally obtrusive system for automatically detecting sleep-disordered breathing, such as cessation of breathing (apnea). The system will enable early and frequent screening for sleep-disordered breathing in a patient's home, significantly increasing patient comfort while cap- turing more representative sleep data compared to a clinical sleep study requiring many attached wires.

* information listed above is at the time of submission.

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