A Visualization Tool for Computer-Aided Diagnosis of Focal Cortical Dysplasia

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43EB017549-01
Agency Tracking Number: R43EB017549
Amount: $150,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2013
Solicitation Year: 2013
Solicitation Topic Code: NIBIB
Solicitation Number: PA12-088
Small Business Information
DUNS: 962655853
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (919) 962-8682
Business Contact
Phone: (919) 924-2828
Email: yuliw@cellmicrosystems.com
Research Institution
DESCRIPTION (provided by applicant): Cell Microsystems is a North Carolina-based start-up biotechnology company whose mission is to commercialize a novel, yet affordable, platform for the efficient isolation of viable, single cells or colonies from a mixedpopulation while the cell/colony remains adherent or encapsulated to a solid surface. The company's IsoRaft technology is based on a unique cell array recently developed at the University of North Carolina (UNC) at Chapel Hill, and represents an ideal opportunity for the translation of an academic technology to the marketplace through the SBIR program. Cell Microsystems has obtained license from UNC to commercialize the technology for a broad market in academic labs, as well as in the biotechnology and pharmaceutical industries. The products consist of disposable microarray (the IsoRaftTM Array) for culturing cells and a simple device for isolating the cell/colony of interest. Prototypes of arrays and devices have been completed and are being tested in anumber of academic labs as an Early Adoption Program (EPA) at nearby research institutes. In this Phase I SBIR proposal, improvements will be made in the IsoRaft array that address feedback from our market needs analysis that will also dramatically improve the manufacturability of the array. Particularly we will institute new materials and a method of manufacture that will enable commercial fabrication of a flat, transparent, biocompatible array of micro-molded elements. The use IsoRaft technology for cellculture, imaging and isolation applications will be conducted by our academic collaborator at UNC. Our goal is to expand the use of this technology for cell research to the large community in the life science market. The studies in Phase I will deliver a2nd generation consumable array that can be mass manufactured to provide a flexible, powerful, yet cost-effective means to perform unique cloning and sorting experiments at significant reductions in cost and time. PUBLIC HEALTH RELEVANCE PUBLICHEALTH RELEVANCE: The novel cell sorting technology being developed by Cell Microsystems Inc. will have broad applications in various health and scientific related area of research.

* Information listed above is at the time of submission. *

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