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Evidence-Based Pain Intervention for Veterans: Leveraging Mobile and Social Media

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43GM108122-01
Agency Tracking Number: R43GM108122
Amount: $190,714.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIGMS
Solicitation Number: PA12-088
Timeline
Solicitation Year: 2013
Award Year: 2013
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
3521 SILVERSIDE ROAD, SUITE 1-K, QUILLEN BLDG
WILMINGTON, DE 19810-
United States
DUNS: 557435273
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 BARRY BOYES
 (302) 981-0853
 bboyes@advanced-materials-tech.com
Business Contact
 JOSEPH DESTEFANO
Phone: (302) 477-2510
Email: joedestefano@advanced-materials-tec
Research Institution
 Stub
Abstract

DESCRIPTION: Life sciences research and other critical bioanalytical applications would strongly benefit from faster and higher resolution liquid chromatographic (HPLC) separations for both small molecules and larger molecules such as proteins, peptides,glycopeptides, and glycans. Many HPLC separations of biomedical interest, such as proteomic or glycomic profiling, require hours or days for resolution of a single sample. Due to the complexity of biological samples, there are many examples in the currentresearch literature that combine multiple dimensions of HPLC separations, often with online mass spectroscopy (MS). Although very time consuming, this approach has yielded useful information on protein expression and post-translational modifications, the biological processes underlying protein expression and modifications, and the effects thereon of development, disease state, and various environmental and genetic factors. In various complex bioanalytical workflows, high efficiency LC separations are a fundamental part of the analytical systems, and the time to achieve high resolution separations of complex biological samples is a great bottleneck. This proposal describes an approach to improve the separation efficiency of HPLC by extending our proprietary Fused-Core silica platform technology to non-spherical superficially porous particals, including ellipsoids, providing significantly faster and higher resolution separations. Our objectives are to create 2.5-5 ?m diameter ellipsoidal superficially porous Fused-Core silica particles, and to load these materials efficiently into HPLC column formats. The goals of the proposed work could yield very high performance chromatographic products, greater than those currently available, to be applied broadly in analysis of complex biological samples, pharmaceutical and biopharmaceutical applications, in fact in any current application that uses HPLC methods. The separations technology described will directly lead to useful products for which there is a significant technical and market demand. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: High pressure liquid chromatography is the most widely used analytical method to separate mixtures of molecules, allowing measurement of quantities and identities of materials in a mixture. This method is broadly used in biomedical research, as well as in the creation, manufacture and control of therapeutic interventions. The current proposal is to use new knowledge in materials science and chemistry to enable faster and more efficient separations by liquid chromatography, saving time and money, as well as enabling new uses of the method to understand the structure and function of biological molecules.

* Information listed above is at the time of submission. *

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