Novel Design of a Fast-On/Fast-Off Insulin Analog for Closed-Loop Systems

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$150,000.00
Award Year:
2013
Program:
SBIR
Phase:
Phase I
Contract:
1R43GM108261-01
Agency Tracking Number:
R43GM108261
Solicitation Year:
2013
Solicitation Topic Code:
NIGMS
Solicitation Number:
PA12-088
Small Business Information
MASSTECH, INC.
6992 Columbia Gateway Drive, ste 160, Columbia, MD, 21046-2885
Hubzone Owned:
N
Socially and Economically Disadvantaged:
Y
Woman Owned:
N
Duns:
123310083
Principal Investigator:
EUGENE MOSKOVETS
(443) 539-1710
moskovets@apmaldi.com
Business Contact:
ARNOLD LEE
(443) 539-1710
alee@apmaldi.com
Research Institution:
Stub




Abstract
DESCRIPTION: Significant increase in the efficiency and speed of MS-based tissue imaging (IMS) performed at atmospheric conditions using high-resolution mass spectrometer will have a profound impact on method applications to the entire analytical field ofcharacterization of biomarkers in tissues. At present, the efficiency of the MS-based tissue imaging is limited by low sensitivity. We propose to employ a separate post-ionization step to increase the ion yield from the material ablated by laser from thetissues. To demonstrate high-throughput IMS analysis based on the proposed post-ionization technique, we plan to modify the house-built compact UV laser system capable of generation high-intensity laser pulses at very high repetition rate. PUBLICHEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Mass spectrometry (MS) analysis of tissues is currently used for profiling of known or search for new biomarkers in cancer-related studies. We plan to develop a novel method that significantly improves sensitivity, dynamics range, and throughput of MS-based tissue imaging. This high-throughput method will operate at atmospheric conditions and can be also applied for a characterization of proteins in 2D gels.

* information listed above is at the time of submission.

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