A new hemagglutination method for blood grouping

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43HL117557-01
Agency Tracking Number: R43HL117557
Amount: $127,523.00
Phase: Phase I
Program: SBIR
Awards Year: 2013
Solicitation Year: 2013
Solicitation Topic Code: NHLBI
Solicitation Number: PA12-088
Small Business Information
DUNS: 139604156
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (973) 919-5707
Business Contact
Phone: (908) 904-1100
Email: sbystryak@allisystems.com
Research Institution
DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to develop a novel quantitative particle agglutination technology for improving the performance of blood typing assays. The conventional hemagglutination blood typing assays have serious drawbacks such as limited sensitivity, long time of incubation, subjectivity and large amount of reagents. It is in this context that we propose to develop a new technology, which is free from the aforementioned limitations of the conventional hemagglutination assays. The proposed immunoassay is a sensitive and rapid method that utilizes inexpensive instrumentation. Significantly, the method presents a general approach for enhancement and detection of agglutination of particles of different origin, including latex, silica microparticles, and biologial cells. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: The development of this method will allow one to obtain quantitative results, increase the sensitivity of particle and red cellagglutination assays, and reduce time of analysis without compromising the cost per test. Successful completion of these studies will result in a substantial business opportunity to license the technology and manufacture commercial products, which will bebeneficial for public health.

* Information listed above is at the time of submission. *

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