Rapid Identification of Pathogenic Bacteria and Sepsis Diagnosis

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$1,956,109.00
Award Year:
2013
Program:
SBIR
Phase:
Phase II
Contract:
2R44AI094781-02
Award Id:
n/a
Agency Tracking Number:
R44AI094781
Solicitation Year:
2013
Solicitation Topic Code:
NIAID
Solicitation Number:
PA10-123
Small Business Information
500 AUSTRALIAN AVE S, STE 120, WEST PALM BEACH, FL, 33401-6223
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
827877486
Principal Investigator:
RAY MARTINO
(650) 938-6200
rmartino@isensesystems.com
Business Contact:
RAY MARTINO
(408) 390-1900
rmartino@isensesystems.com
Research Institution:
Stub




Abstract
DESCRIPTION (provided by applicant): Sepsis is the tenth-leading cause of death in the United States and the second-leading cause of death in the intensive care unit (ICU). Sepsis kills over 215,000 Americans each year - more than breast cancer, lung cancer, and prostate cancer combined. Rapid identification and determination of antibiotic susceptibility is critical fo effective treatment of infected patients. Phase I successfully demonstrated the iSense system's ability to discriminate bacterial species and strain 4-fold faster than legacy methods identify species alone. In Phase I iSense also successfully demonstrated the ability to determine strain-specific susceptibility to antibiotic therapy more than 1 day faster than conventional practice. Phase II aims address application to clinical human specimens along with development of instruments and media appropriate for commercial use. The ultimate goal of this research is to develop and commercially deploy an automated blood culture system that can diagnosesepsis, identify the species and strain of the infecting organism, and determine antibiotic susceptibility all in less than 24 hours from the lab's receipt of primary specimen. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Sepsis kills over 215,000 Americans each year - more than breast cancer, lung cancer, and prostate cancer combined. Rapid identification and determination of antibiotic susceptibility is critical for effective treatment of infected patients The ultimate goal of this researchis to develop and an automated system that returns results in less than 24 hours, 3 times faster than current practices.

* information listed above is at the time of submission.

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