SBIR TOPIC 315: DEVELOPMENT OF COMPANION DIAGNOSTICS: ENABLING PRECISION MEDICINE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$266,199.00
Award Year:
2013
Program:
SBIR
Phase:
Phase I
Contract:
N43CA130037
Award Id:
n/a
Agency Tracking Number:
N43CA130037
Solicitation Year:
2013
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
1551 Eastlake Avenue East, Suite 200, SEATTLE, WA, 98102-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
832591544
Principal Investigator:
MARK RIEDER
(206) 659-0067
MRIEDER@ADAPTIVEBIOTECH.COM
Business Contact:
MARK RIEDER
(206) 659-0067
MRIEDER@ADAPTIVEBIOTECH.COM
Research Institution:
Stub




Abstract
Immunotherapy has emerged as a promising method to treat several cancers. In 2012 the FDA approved a new immunotherapy agent, ipilimumab, for metastatic melanoma. Ipilimumab activates T-cells and globally increases the adaptive immune response and resultsin an enhanced response to the cancer. In a subset of patients, this leads to longer Progression Free Survival (PFS), and in some cases remission. However, there is no companion diagnostic available to predict responders. The goal of this project is to develop a deep sequencing assay to measure the immune repertoire and a corresponding diagnostic protocol that differentiates ipilimumab responders from non-responders. Currently, while many of patients experience immune mediated side effects related to ipilimumab, less than 10% of patients cancer responds to therapy. Developing a companion diagnostic that differentiates responders from non-responders would protect non-responders from unnecessary side-effects. PUBLIC HEALTH RELEVANCE

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government