SBIR TOPIC 315: DEVELOPMENT OF COMPANION DIAGNOSTICS: ENABLING PRECISION MEDICINE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N43CA130037
Agency Tracking Number: N43CA130037
Amount: $266,199.00
Phase: Phase I
Program: SBIR
Awards Year: 2013
Solicitation Year: 2013
Solicitation Topic Code: NCI
Solicitation Number: N/A
Small Business Information
ADAPTIVE TCR CORPORATION
1551 Eastlake Avenue East, Suite 200, SEATTLE, WA, 98102-
DUNS: 832591544
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MARK RIEDER
 (206) 659-0067
 MRIEDER@ADAPTIVEBIOTECH.COM
Business Contact
 MARK RIEDER
Phone: (206) 659-0067
Email: MRIEDER@ADAPTIVEBIOTECH.COM
Research Institution
 Stub
Abstract
Immunotherapy has emerged as a promising method to treat several cancers. In 2012 the FDA approved a new immunotherapy agent, ipilimumab, for metastatic melanoma. Ipilimumab activates T-cells and globally increases the adaptive immune response and resultsin an enhanced response to the cancer. In a subset of patients, this leads to longer Progression Free Survival (PFS), and in some cases remission. However, there is no companion diagnostic available to predict responders. The goal of this project is to develop a deep sequencing assay to measure the immune repertoire and a corresponding diagnostic protocol that differentiates ipilimumab responders from non-responders. Currently, while many of patients experience immune mediated side effects related to ipilimumab, less than 10% of patients cancer responds to therapy. Developing a companion diagnostic that differentiates responders from non-responders would protect non-responders from unnecessary side-effects. PUBLIC HEALTH RELEVANCE

* information listed above is at the time of submission.

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