SBIR TOPIC321:CHEMICALLY DEFINED GLYCAN LIBRARIES FOR REFERENCE STANDARDS AND GLY

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N43CA130039
Agency Tracking Number: N43CA130039
Amount: $299,034.00
Phase: Phase I
Program: SBIR
Awards Year: 2013
Solitcitation Year: 2013
Solitcitation Topic Code: NCI
Solitcitation Number: N/A
Small Business Information
LIFE BIOSCIENCE, INC.
5201 VENICE AVE. NE, SUITE D, ALBUQUERQUE, NM, 87113-2337
Duns: 8616322
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 JIAN ZHANG
 (866) 559-8982
 JIAN.ZHANG@LIFEBIOSCIENCE.COM
Business Contact
 JIAN ZHANG
Phone: (866) 559-8982
Email: JIAN.ZHANG@LIFEBIOSCIENCE.COM
Research Institution
 Stub
Abstract
O-glycosylation is one type of important protein modification and plays crucial roles in many cellular processes. Currently, there is limited commercial source for the glycosyl amino acid building blocks that can be utilized in glycopeptide synthesis. Inthis Phase I project, Life BioScience Inc. (LBSI) proposed to utilize its established glycan technologies and extensive research experience of its employees in carbohydrate chemistry to synthesize a chemical library of 36 O-linked core structures on amino acids (Ser/Thr) that have been protected by Fmoc for further glycopepetide synthesis. The proposed glycan compounds will be well purified (gt98% purity) and structurally identified by NMR and Mass Spectrometry. New carbohydrate and peptide synthesis strategies including microwave-assisted synthesis, formation of alpha-O-GaINAc conformation, and [2+1] synthetic approach, will be empolyed in the sythetic routes leading to O-glycosyl amino acid building blocks. In addition, LBSI will collaborate with Dr. David Live at CCRC in Phase I to assemble the glycosyl building blocks to glycopeptides for proof-of-concept demonstration. At the end of the Phase I project, LBSI will provie the purified glycan samples to a NIGMS-designated screen center for the useas analytical standards in structural studies and carbohydrate-based high throughput assays. PUBLIC HEALTH RELEVANCE

* information listed above is at the time of submission.

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