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Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: N43CA130051
Agency Tracking Number: N43CA130051
Amount: $300,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: N/A
Solicitation Year: 2013
Award Year: 2013
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
DEL MAR, CA 92014-3805
United States
DUNS: 68373964
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (858) 205-3607
Business Contact
Phone: (858) 205-3607
Research Institution

This proposal outlines a plan to synthesize standard samples of a range of glycans as reference compounds in glycomics research. Cassia, LLC shall work in collaboration with the Paulson laboratory at The Scripps Research Institute to make these compoundscommercially available to the research community. The Specific Aims include enzymatic synthesis of 20-32 glycans as either terminal fragments, or N- or O-linked glycans. In addition, these compounds shall be synthesized as heavy versions including 13Cisotope labels to facilitate their use as internal standards for identification and quantitation of glycans using mass spectrometry. The glycans shall be characterized using NMR and mass spectrometry, and the compounds shall be supplied as standards forthe National Institute of General Medical Sciences (NIGMS) microarray facility. The specific aims in Phase I of this Fast Track SBIR proposal are designed to supply the first wave of glycan products, and to begin to transfer the technology of enzymaticglycan synthesis from the Paulson laboratory to Cassia. These aims set the foundation for synthesis of expanded glycan libraries in Phase II, and successful commercialization of a broad range of glycan reference compounds in Phase III Commercialization.PUBLIC HEALTH RELEVANCE

* Information listed above is at the time of submission. *

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