PEDIATRIC BODY LEAD BURDEN BY X-RAY FLUORESCENCE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 13745
Amount: $481,018.00
Phase: Phase II
Program: SBIR
Awards Year: 1992
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
33 Cherry Hill Dr, Danvers, MA, 01923
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Douglas E Burger
 (508) 777-5410
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THREE TO FOUR MILLION YOUNG CHILDREN FROM ALL LEVELS OF SOCIETY ARE EXPOSED TO ENVIRONMENTAL SOURCES OF LEAD AT CONCENTRATIONS THAT PLACE THEM AT RISK FOR ADVERSE HEALTH EFFECTS. YET, THERE IS NO TOOL AVAILABLE FOR MEASURING TOTAL PEDIATRIC BODY BURDEN OF LEAD. THIS PROJECT WILL DEVELOP AN X-RAY FLUORESCENCE (XRF) INSTRUMENT THAT WILL ALLOW MEASUREMENT OF BODY LEAD BURDEN IN CHILDREN IN VIVO AND NONINVASIVELY. EXPERIENCE GAINED FROM THE DEVELOPMENT OF AN AUTOMATED STATE-OF-THE-ART ADULT XRF INSTRUMENT DURING PREVIOUS RESEARCH SERVES AS THE STEPPING STONE. USING A NOVEL DETECTOR DESIGN, A UNIQUE ANALYSIS ALGORITHM, AND INCREASES IN COLLECTION SOLID ANGLE TO IMPROVE THROUGHPUT, THIS PHASE I PROGRAM WILL PROVE THE FEASIBILITY OF USING XRF AS A PEDIATRIC SCREENING TOOL. THE ULTIMATE INSTRUMENT AFFORDS A UNIQUE CAPABILITY AS: (1) A DIAGNOSTIC TOOL IN DETERMINING THE PRESENCE OF ELEVATED BONE LEAD LEVELS, (2) A MASS SCREENING DEVICE FOR INDICATION OF CHRONIC LOW-LEVEL LEAD EXPOSURE, AND (3) AMONITORING DEVICE IN FOLLOWING PROGRESS DURING CHELATION THERAPY.

* Information listed above is at the time of submission. *

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