Brain-activity during sedation predicting post-sedation explicit-memory

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$437,343.00
Award Year:
2009
Program:
SBIR
Phase:
Phase I
Contract:
1R43GM086927-01A2
Award Id:
93812
Agency Tracking Number:
GM086927
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ABRATECH CORPORATION, 475 GATE 5 RD, STE 213, SAUSALITO, CA, 94965
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
624508917
Principal Investigator:
DON JEWETT
(415) 331-8775
DLJ@ABRATECH.COM
Business Contact:
DON JEWETT
() -
dlj@abratech.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): This project will study electrical brain-activity measures that may be able to indicate whether or not long-term memory is occurring, under light sedation. The goal is to develop a brain-monitor to be used in the operat ing room to ascertain if a patient's level of anesthesia has become too light, such that the patient can experience pain, and understand what is occurring in the operating room, and remember the experience. Such an event is rare, but traumatic. No present brain-analysis system accurately distinguishes the boundary in light anesthesia, between that level in which there will be explicit-memory and that level in which explicit-memory is missing. The fundamental scientific goal is to provide a tool for further investigations of the mechanisms of explicit memory, in animals as well as humans. If the goal were achieved, it would offer the chance to develop a clinical tool for analysis, diagnosis, or prognosis of medical conditions involving changes in memory (for which present tools are often inadequate). The project is health-related in that it addresses a problem in clinical medicine, and will provide a solution to that problem, if successful. PUBLIC HEALTH RELEVANCE: This project is relevant to public health bec ause it studies humans and their reactions to sedation under anesthetic agents, to find a way to detect whether, in an operation, the patient is alert enough to remember experiences. This is a rare event in surgery, but should be prevented, if possible, wi th the techniques that will be developed in this research.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government