SBIR Phase I: Osteoconduction Determination of Mineral Coated Silicon Dioxide Nanosprings

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$150,000.00
Award Year:
2013
Program:
SBIR
Phase:
Phase I
Contract:
1315050
Award Id:
n/a
Agency Tracking Number:
1315050
Solicitation Year:
2012
Solicitation Topic Code:
BC
Solicitation Number:
n/a
Small Business Information
PO Box 105, 30545 E Hayden Loop, Cataldo, ID, 83810-0105
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
078537604
Principal Investigator:
Jamie Hass
(208) 660-7297
jlhass.mj3@gmail.com
Business Contact:
Jamie Hass
(208) 660-7297
jlhass.mj3@gmail.com
Research Institution:
Stub




Abstract
This Small Business Innovation Research Phase 1 project addresses the failure of osseointegration, the lack of bonding between an orthopedic device and bone. Failure of the implant does occur with an unacceptably high rate (8-20%). The main driver for revision surgery is aseptic loosening of the implant, which occurs at a nanoscale. This can be very detrimental to the patient since the revised implants have higher complication rates. The research objective is to develop an orthopedic implant coating that mimics both the scaffolding and mineral structure of healing woven bone. Coated nanosprings, a synthetic collagen nanobiomaterial, mimics the scaffolding component of bone. This proposal is directed at developing a mineral layer on the nanosprings to make synthetic woven bone. Nanosprings can be grown on orthopedic devices. Metal alloy coated nanosprings are well tolerated by the body and increase the bone deposition rate, but the procedure is expensive. The mineral used for the proposed coating is inexpensive but lacks the scaffolding effects needed for bone integration. Combining these two synthetic biomaterials would provide the necessary economical scaffolding to facilitate osseointegration. The broader impact/commercial potential of this project to the osteoconductive biomaterial market is vast. The orthopedic market is a multi-billion dollar industry, which will increase as the baby boomer population ages. This technology can be employed in both animal and human devices, such as dental implants, prosthetics, and joint replacements. The potential commercialization options are partnering with an existing orthopedic device manufacturer for this add-on coating, or direct sales to the animal market, and then to the human market as the FDA allows. The coated nanosprings have the ability to greatly increase the rate and hardness of bone deposition. It is hypothesized that this increase around implants can have a significant clinical impact to improve the quality of patient?s lives as well as an economical benefit. This new technology can provide employment for scientists in both biologic and other hard science fields. The nanosprings are an ideal foundation for osteoconductive research. This synthetic collagen allows different coating material to be studied at a nanoscale level. Thus, providing both materials and biologic insight to the osseointegration process.

* information listed above is at the time of submission.

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