Burkholderia antibody molecules for therapeutics and diagnostics

Award Information
Agency:
Department of Defense
Amount:
$149,998.00
Program:
SBIR
Contract:
W911-QY-14-P0160
Solitcitation Year:
2014
Solicitation Number:
2014.1
Branch:
Office for Chemical and Biological Defense
Award Year:
2014
Phase:
Phase I
Agency Tracking Number:
C141-105-0056
Solicitation Topic Code:
CBD14-105
Small Business Information
BIOO Scientific
7050 Burleson Rd., Austin, TX, 78744-3202
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
000000000
Principal Investigator
 Sandesh Subramanya
 Director, Animal Health
 (512) 707-8993
 sandeshs@biooscientific.com
Business Contact
 Lance Ford
Title: Manager of Sponsored Research
Phone: (512) 707-8993
Email: lford@biooscientific.com
Research Institution
N/A
Abstract
Burkholderia pseudomallei and Burkholderia mallei are highly pathogenic Gram-negative bacteria and the causative agents of melioidosis and glanders, respectively. These infections, which occur in humans and other animals, are endemic is wide regions of the developing world. Translational research regarding these pathogens is focused on developing new strategies to detect, treat and ideally protect humans and animals from these infections. In this Phase I SBIR project, we will establish methodologies for the generation of monoclonal antibodies that have high-affinities to Burkholderia antigens. The purpose of these studies is to create new antibody-based prophylactics that can neutralize Burkholderia infections. As a first step, we will isolate carbohydrate antigens from non-pathogenic strains of Burkholderia in forms that will generate appropriate immune responses. We will also assess the relative performance and compatibilities of existing antibodies to bind Burkholderia pathogens, in order to create optimized formulations, which will be assessed for therapeutic benefit in future challenge studies.

* information listed above is at the time of submission.

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