Non-invasive Detection System for Assessment of Oxidative Status

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$499,889.00
Award Year:
2014
Program:
SBIR
Phase:
Phase II
Contract:
W911QY-14-C-0003
Agency Tracking Number:
A2-5504
Solicitation Year:
2012
Solicitation Topic Code:
A12-097
Solicitation Number:
2012.2
Small Business Information
ChromoLogic LLC
180 N Vinedo Ave, Pasadena, CA, 91107-3490
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
000000000
Principal Investigator:
Mark Mackanos
Research Scientist
(626) 381-9974
jaxtelle@chromologic.com
Business Contact:
Naresh Menon
CEO
(626) 381-9974
nmenon@chromologic.com
Research Institution:
n/a
Abstract
To address the Armys need for a non-invasive, compact, robust system to monitor the oxidative status of military personnel, ChromoLogic (CL) proposed and demonstrated during Phase I a OCular Oxidative Stress Monitor (OCOSMO) system based on non-invasive optical measurements of oxidative stress biomarkers that are expressed within the aqueous humor (eye). By building multiple generations of OCOSMO prototypes and performing in vitro tests, CL demonstrated for the first time that cost-effective non-invasive monitoring of oxidative stress biomarkers in real-time is highly feasible. A high specificity panel of biomarkers was identified for determining oxidative stress caused from exercise. Tests with the OCOSMO prototypes showed that these biomarkers can be identified with sensitivity >10x the clinical level needed. In Phase II, CL plans to develop a complete OCOSMO prototype and perform detailed pre-clinical and clinical validation of the technology.

* information listed above is at the time of submission.

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