Nanosphere Beacons for Real-Time Detection In Vivo

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W31P4Q-04-C-R232
Agency Tracking Number: 04SB1-0209
Amount: $98,998.00
Phase: Phase I
Program: SBIR
Awards Year: 2004
Solitcitation Year: 2004
Solitcitation Topic Code: SB041-013
Solitcitation Number: 2004.1
Small Business Information
ACCACIA INTERNATIONAL LLC
1925 Rutland Drive, Suite E, Austin, TX, 78758
Duns: 084994735
Hubzone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: Y
Principal Investigator
 Eulalia Sequeira
 President
 (512) 784-1861
 bioaid@austin.rr.com
Business Contact
 Eulalia Sequeira
Title: President
Phone: (512) 784-1861
Email: bioaid@austin.rr.com
Research Institution
N/A
Abstract
Current techniques for real-time detection of signaling pathways in live cells are limited. Accacia International LLC, will develop better strategies by combining the signaling properties of molecular beacons and aptamer beacons with the advantages of quantum dot photoluminescence to produce quantum dot beacons (QDBs). In order to demonstrate the potential of these novel signaling nanoparticles, Accacia will generate QDBs targeting both mRNA and protein targets. The designs will be tested both in vitro and in vivo. These experiments should provide a solid foundation for the future design and generation of additional QDBs which will potentiate parallel detection of all the components of a cell signaling cascade.

* information listed above is at the time of submission.

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