Nanosphere Beacons for Real-Time Detection In Vivo

Award Information
Agency:
Department of Defense
Branch
Defense Advanced Research Projects Agency
Amount:
$98,998.00
Award Year:
2004
Program:
SBIR
Phase:
Phase I
Contract:
W31P4Q-04-C-R232
Agency Tracking Number:
04SB1-0209
Solicitation Year:
2004
Solicitation Topic Code:
SB041-013
Solicitation Number:
2004.1
Small Business Information
ACCACIA INTERNATIONAL LLC
1925 Rutland Drive, Suite E, Austin, TX, 78758
Hubzone Owned:
N
Socially and Economically Disadvantaged:
Y
Woman Owned:
Y
Duns:
084994735
Principal Investigator:
Eulalia Sequeira
President
(512) 784-1861
bioaid@austin.rr.com
Business Contact:
Eulalia Sequeira
President
(512) 784-1861
bioaid@austin.rr.com
Research Institution:
n/a
Abstract
Current techniques for real-time detection of signaling pathways in live cells are limited. Accacia International LLC, will develop better strategies by combining the signaling properties of molecular beacons and aptamer beacons with the advantages of quantum dot photoluminescence to produce quantum dot beacons (QDBs). In order to demonstrate the potential of these novel signaling nanoparticles, Accacia will generate QDBs targeting both mRNA and protein targets. The designs will be tested both in vitro and in vivo. These experiments should provide a solid foundation for the future design and generation of additional QDBs which will potentiate parallel detection of all the components of a cell signaling cascade.

* information listed above is at the time of submission.

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