Oligonucleotide Enzyme Surrogate (OnES)
Department of Defense
Office for Chemical and Biological Defense
Agency Tracking Number:
Solicitation Topic Code:
Small Business Information
ACCACIA INTERNATIONAL, INC.
One Tech Plaza, 2113 Wells Branch Parkway, Sui, Austin, TX, 78728
Socially and Economically Disadvantaged:
AbstractHistorically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates are ingested, the use of proteinaceous enzymes such as OPH can be problematic because of their tendency to produce an immune response. In order to avoid this issue, Accacia International will manipulate DNA oligonucleotides using a novel and innovative selection method. DNA aptamers will be selected through the Systematic Evolution of Ligands by EXponential enrichment (SELEX) method to accomplish the task of creating an enzyme surrogate.
* information listed above is at the time of submission.