Oligonucleotide Enzyme Surrogate (OnES)

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: FA8650-09-C-6030
Agency Tracking Number: C081-108-0102
Amount: $699,754.00
Phase: Phase II
Program: SBIR
Awards Year: 2009
Solicitation Year: 2008
Solicitation Topic Code: CBD08-108
Solicitation Number: 2008.1
Small Business Information
One Tech Plaza, 2113 Wells Branch Parkway, Suite 6900, Austin, TX, 78728
DUNS: 084994735
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Jean Bishop
 Principal Investigator
 (512) 617-3387
Business Contact
 Eula Sequeira
Title: President
Phone: (512) 782-8204
Email: eula@accaciabio.com
Research Institution
Nerve agents (NA) such as sarin, soman, tabun or VX are organophosphate compounds similar to those used as pesticides but with much higher toxicity that can cause death within minutes. Use of NA weapons of mass destruction has become a real threat since the Iraq–Iran war in the 1980s and the sarin attacks against civilians in Japan in 1994 and 1995. Nerve agents are relatively simple and inexpensive to produce, transport, and deploy and are the most toxic of the known chemical warfare agents. Therefore, there is an increasing threat of their use for terrorist purposes against military and civilian populations. This calls for effective preventive and therapeutic preparedness. Currently available antidotes are not very effective. We propose to develop adaptazymes (catalytic oligonucleotides) that would hydrolyze soman and other NAs and organophosphates. We will partner with Battelle, Texas A&M University and Archemix to develop and market our adaptazyme technology. Such adaptazymes would find commercial application in preventive and therapeutic treatment of NA and organophosphate pesticide poisoning in humans and animals. These adaptazymes would also be very useful for decontamination of environmental deposits of organophosphates.

* Information listed above is at the time of submission. *

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