Ultra-High-Density Arrays for Genome Research

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 MH52939-1,
Agency Tracking Number: 25198
Amount: $51,600.00
Phase: Phase I
Program: SBIR
Awards Year: 1994
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
25025 I-45 North, Ste 525, The Woodlands, TX, 77380
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Don Smith
 (713) 298-5053
Business Contact
Phone: () -
Research Institution
N/A
Abstract
We will develop porous silicon based detector chips for the identification of biomoleculefragments. Patches of porous silicon on a silicon wafer act as active sieves, loaded with taggingmolecules, where during passage through it biomolecule fragments are identified by their response afterattachment of a tag to a modulated electric field applied across the porous patch. This technique, ifsuccessful, will make the determination of the structure of large molecules by testing simultaneouslymany fragments with many tags feasible. The production of devices using porous silicon is part of theresearch done by a group at Texas A&M University (TAMU). Schemes for simultaneously testing manybiomolecule samples at close spacing on small sample carriers are being developed at DNA TechnologyLaboratory. In phase I, ATC would test prototype wafers with few porous silicon areas built by theTAMU group with samples provided by DNA Technology Lab to evaluate the principles of the technique.In a follow-on Phase II effort, ATC would build several high-density test chips with matching samplefeeders and seek opportunities and partners for commercialization of production of laboratory analysisdevices.

* Information listed above is at the time of submission. *

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