Chemical Casualty Care: Hydrogel Nanoparticle Aggregates as Wound Dressings Following Debridement of Cutaneuous Vesicant Injuries

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-06-C-0026
Agency Tracking Number: A052-131-1312
Amount: $69,988.00
Phase: Phase I
Program: SBIR
Awards Year: 2005
Solicitation Year: 2005
Solicitation Topic Code: A05-131
Solicitation Number: 2005.2
Small Business Information
2600 Stemmons Freeway, Suite 176, Dallas, TX, 75207
DUNS: 607812414
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 John St. John
 Senior Scientist
 (214) 905-5100
 jvs@accesspharma.com
Business Contact
 Stephen Thompson
Title: Chief Financial Officer
Phone: (214) 905-5100
Email: sbt@accesspharma.com
Research Institution
N/A
Abstract
The proposed research will demonstrate the utility of hydrogel nanoparticle aggregates as bandages for post-debridement vesicant injuries. Dehydrated hydrogel nanoparticles in powder form are applied to the surface of a wound. The nanoparticles aggregate immediately and form a continuous hydrogel film that absorbs exudate and protects the wound surface. Studies show that an aggregate film controls the release of antibiotics, painkillers, protein-based growth factors, and steroids for periods ranging from weeks to months. The research will apply the wound dressing to burns in an animal model and assess the healing and local pharmacokinetics for released therpeutics.

* Information listed above is at the time of submission. *

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