High Spatial Resolution Ultrafast Sum-Frequency Generation Microscope

Award Information
Agency: Department of Energy
Branch: N/A
Contract: DE-SC0011365
Agency Tracking Number: 210212
Amount: $149,996.72
Phase: Phase I
Program: STTR
Awards Year: 2014
Solitcitation Year: 2014
Solitcitation Topic Code: 07a
Solitcitation Number: DE-FOA-0000969
Small Business Information
Physics Materials and Applied Mathematics Research LLC
1665 E. 18th Street, Suite 112, Tucson, AZ, 85719-6808
Duns: 058268652
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Alexander McCourt
 (520) 903-2345
Business Contact
 Kevin Kremeyer
Title: Dr.
Phone: (520) 882-7349
Email: kremeyer@physics-math.com
Research Institution
 University of California, Irvine (UCI)
 Natural Sciences II
Irvine, CA, 92697-1075
 () -
 Nonprofit college or university
Vibrationally resonant sum-frequency generation (SFG) spectroscopy is a second order nonlinear optical technique that features high chemical selectivity and a set of selection rules that makes it an ideal complement to coherent Raman scattering (CRS) as an imaging tool. Attempts have been made to construct high-resolution, high speed SFG microscopes, but to date both the resolving power and image acquisition speed have been limited to unacceptable ranges due to the lack of purely refractive optical elements capable of operating without deleterious chromatic effects over the wavelengths of the two beams used to produce SFG in samples. In order to increase both the spatial resolution and the scanning speed of SFG microscopes, we will design custom achromatic optical elements for operation at wavelengths in the near- and mid-infrared regions. Additionally, we use these improvements to incorporate both CRS and second harmonic generation into the microscope. Commercial Applications and Other Benefits: The proposed technology will introduce a microscope that will greatly enhance researchers ability to image fragile and sensitive materials without the use of exogenous agents. Examples include biological tissues, works of art and ancient objects of archeological significance. In particular, a multimodal microscope incorporating SFG and CRS will provide researchers with the ability to image biological tissue structure that cannot be currently imaged without labels or destructive methods. Such a microscope could profoundly affect fields of study such as medicine and biomechanical engineering.

* information listed above is at the time of submission.

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