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Next-Generation Voltage Sensitive Dyes for Cell Bioelectricity Measurements

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: D14PC00119
Agency Tracking Number: D141-002-0008
Amount: $102,800.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: SB141-002
Solicitation Number: 2014.1
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): 2014-05-28
Award End Date (Contract End Date): 2015-04-28
Small Business Information
267 Boston Road Suite 11
North Billerica, MA 01862-2310
United States
DUNS: 962321381
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Larry Takiff
 (978) 362-2642
Business Contact
 Douglas Weber
Title: program manager
Phone: (703) 526-2856
Research Institution

Akita Innovations proposes to develop the next generation of voltage-sensitive dyes for cellular bioelectricity measurements by engineering electric field sensitivity into a class of highly fluorescent dyes which heretofore have not been used for this purpose. The much higher brightness of these dyes will improve the sensitivity of the voltage measurements. Akita will also develop a method of targeting these dyes, as well as existing voltage sensitive dyes, to particular cell types and regions by conjugating them to polypeptides with appropriate specificity.

* Information listed above is at the time of submission. *

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