IMPROVED NON-INVASIVE BLOOD GLUCOSE MONITORING DEVICE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$140,992.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43DK059690-01A1
Award Id:
60821
Agency Tracking Number:
DK059690
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ACIONT, INC., 350 WEST 800 NORTH, STE 250, SALT LAKE CITY, UT, 84103
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
ABDELHALIMGHANEM
(801) 359-3461
ADMIN@ACIONT.COM
Business Contact:
HIGUCHII
(801) 359-3461
ACIONT@NETWORLD.COM
Research Institute:
n/a
Abstract
The accurate measurement of blood glucose concentration is important in the management of diabetes. Current methods of glucose monitoring involve piercing the skin and collecting blood samples for analysis up to four times daily or more. Even the non-invasive Glucowatch tm glucose monitoring system requires twice daily blood collection for calibration. This original, innovative invention will decrease and maintain the electrical resistance of the skin at a constant level. This allows for a controlled, increased passive or electroosmoticatly driven migration of glucose outwardly through the skin into a biosensor for analysis. By creating a constant permeability and avoiding a capacitance effect, we will be able to reproducibly extract and analyze glucose through the skin, minimizing the need for frequent calibration. Our long-term goal is to commercialize an iontophoretic device that will allow for the accurate and reproducible extraction of glucose from the skin or underlying subcutaneous space. Phase I research will study the linearity between glucose extraction and donor solution concentration in vitro and in vivo and demonstrate the advantage of our approach over the Glucowatch tm We will study glucose flux through human epidermis using a variety of protocols to optimize stratum corneum permeation enhancement and minimize intra- and inter-subject variability.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government