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Porphyrin-DNA Origami Constructs as Bioscavengers for Organophosphates

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911SR-14-C-0033
Agency Tracking Number: C141-104-0046
Amount: $149,999.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD14-104
Solicitation Number: 2014.0
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): 2014-09-23
Award End Date (Contract End Date): 2015-03-23
Small Business Information
11260 Roger Bacon Drive Suite 406, Reston, VA, 20190-5203
DUNS: 000000000
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 David Danley
 VP, Vaccine Development
 (703) 689-9689
 dave@parabon.com
Business Contact
 Paula Gawthorp-Armentrout
Title: VP&Corporate Officer
Phone: (703) 689-9689
Email: parmentrout@parabon.com
Research Institution
 Stub
Abstract
The recent use of organophosphate (OP) nerve agents against combatants and civilians in Syria has validated the importance of developing new drugs and biologics that sequester and catalytically degrade organophosphate (OP) nerve agents in the body before they cause morbidity and mortality. We propose to develop a method for the sequestration of OP simulants via porphyrin-DNA constructs. Constructs will be designed and synthesized based upon published approaches and molecular modeling and will be compatible with integration into DNA origami. The DNA origami, in turn, can be modified to meet CBD14-104 requirements for extended serum half-life, lyophilization, and stable shelf life, but equally important, is their biocompatibility, ability to incorporate other constructs for nerve agent sequestration, and ease of production. Successful demonstration of the proposed approach offers the opportunity for development of a novel biopharmaceutical(s) to protect military personnel against OP nerve agents and toxic industrial chemicals.

* Information listed above is at the time of submission. *

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