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A Miniature Autoinjector for Multicomponent Drugs and Vaccines

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911QY-14-C-0047
Agency Tracking Number: C2-0379
Amount: $523,613.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: CBD13-106
Solicitation Number: 2013.1
Timeline
Solicitation Year: 2013
Award Year: 2014
Award Start Date (Proposal Award Date): 2014-06-30
Award End Date (Contract End Date): 2015-06-30
Small Business Information
NH, Hanover, NH, 03755-3116
DUNS: 072021041
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Michael Jaeger
 Princinpal Investigator
 (603) 643-3800
 mdj@creare.com
Business Contact
 Robert Kline-Schoder
Title: President
Phone: (603) 643-3800
Email: contractsmgr@creare.com
Research Institution
 Stub
Abstract
Chemical, biological, or toxin attacks in military and civilian settings are a serious and growing concern. Standard first aid for exposure to some chemical warfare agents and toxins includes the immediate administration of relevant antidotes using an autoinjector. When an attack occurs, pre-filled autoinjectors must be immediately available and thus highly portable, and they must be suitable for use by nonmedical personnel. Similarly, rapid distribution and administration of targeted vaccines is critical during biological attacks. Storage of drug formulations as separate components within the injector (e.g., a dry medication and a diluent) can significantly extend the shelf life of many medications. Creare proposes to develop a novel miniaturized autoinjector that automatically mixes two or more pre filled components immediately prior to injection. The drug storage and reconstitution method uses Creare"s recently patented technology for disposable, pre-filled drug cartridges and is applicable to single-component, dry/wet, liquid/liquid, and multicomponent combinations. In Phase I, we developed feasible autoinjector designs and demonstrated key autoinjector functions. In this Phase II project, we will optimize autoinjector platform designs, manufacture prototype devices, and test the prototypes to demonstrate functionality, reliability, and overall suitability for military and civilian use. We will also begin preparing for FDA product approval.

* Information listed above is at the time of submission. *

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